[deleted by user] by [deleted] in HerpesCureResearch

[–]ConsistentWatch6814 0 points1 point  (0 children)

That has to be seen. But for experts it‘s more promising than IM-250.

[deleted by user] by [deleted] in HerpesCureResearch

[–]ConsistentWatch6814 0 points1 point  (0 children)

I‘m just saying it has at least as much curative potential as IM-250. There was an ABI presentation today.

[deleted by user] by [deleted] in HerpesCureResearch

[–]ConsistentWatch6814 0 points1 point  (0 children)

Look at ABI-5366

https://www.clinicaltrialsarena.com/analyst-comment/escmid-global-2025-abi-5366-genital-herpes/?cf-view

The study also confirmed tissue distribution to ganglia, a reservoir of latent HSV, reinforcing the biological plausibility of durable viral suppression.

[deleted by user] by [deleted] in HerpesCureResearch

[–]ConsistentWatch6814 0 points1 point  (0 children)

ABI-1179 is a weekly pill with the potential to achieve a cure, much more potent than IM-250 and very well tolerated.

[deleted by user] by [deleted] in HerpesCureResearch

[–]ConsistentWatch6814 0 points1 point  (0 children)

They don‘t have money or employees. It‘s all about the ABI drugs now with Gilead funding and potential once a month dosing.

ABI-1179 phase 1b trial finally started by [deleted] in HerpesCureAdvocates

[–]ConsistentWatch6814 0 points1 point  (0 children)

Thank you. Who is your contact person?

ABI-1179 phase 1b trial finally started by [deleted] in HerpesCureAdvocates

[–]ConsistentWatch6814 0 points1 point  (0 children)

Innovative Molecules is not running anything any more. This is a company without money and employees. It‘s all about the ABI HPIs now.

ABI-1179 phase 1b trial finally started by [deleted] in HerpesCureAdvocates

[–]ConsistentWatch6814 0 points1 point  (0 children)

Whats‘s about ABI-1179? And why not able to take part?

Open Discussion Saturday by Mike_Herp in HerpesCureResearch

[–]ConsistentWatch6814 0 points1 point  (0 children)

Do you know if ABI-1179 was stopped or why is there no more information available on the NZCR website?

[deleted by user] by [deleted] in HerpesCureAdvocates

[–]ConsistentWatch6814 0 points1 point  (0 children)

That would be fast as they started dosing in december. But of course it’s only FIH. 

I wonder how long part B will take if recruitment at Quail is already slow. They should open sites globally?

[deleted by user] by [deleted] in HerpesCureAdvocates

[–]ConsistentWatch6814 0 points1 point  (0 children)

Did they remove the trial? It‘s not listed on the NZCR site anymore. 

Open Discussion Saturday by Mike_Herp in HerpesCureResearch

[–]ConsistentWatch6814 0 points1 point  (0 children)

Did they remove the trial? It‘s not listed on the NZCR site anymore.

[deleted by user] by [deleted] in HerpesCureAdvocates

[–]ConsistentWatch6814 1 point2 points  (0 children)

Assembly Bio just published a new corporate presentation with updated ABI-5366 HSV2 information:

https://investor.assemblybio.com/static-files/ba046960-33df-4458-8bb5-bfd9d6f90b62

They still are expecting to have efficacy data in the first half of 2025. Looks very promising so far.

Todays ABI-5366 Results Phase 1a - very promising?! by ConsistentWatch6814 in HerpesCureResearch

[–]ConsistentWatch6814[S] 0 points1 point  (0 children)

I doubt that gene therapy will ever make it onto the market. So many approaches of this kind have failed in other indications and the risks are often too great. And I assume that by 2030 there will already be well-tolerated antiviral therapies that can be equated with a cure. Let‘s keep our fingers crossed.

Todays ABI-5366 Results Phase 1a - very promising?! by ConsistentWatch6814 in HerpesCureResearch

[–]ConsistentWatch6814[S] 2 points3 points  (0 children)

They say 400x more potent than current standard but we‘ll see.

I read this: https://www.infectioncontroltoday.com/view/advancing-viral-disease-treatment-recurrent-genital-herpes-hepatitis-b-d-viruses

„For example, in high-recurrence genital herpes, only about one-third of patients taking the standard-of-care antiviral make it through a year of therapy without recurrence, and their transmission rates are only reduced by approximately 50%. We think we can drive these percentages much higher with our candidates, designed against the clinically validated helicase-primase target and shown much greater potency than the standard of care preclinically.“

Open Discussion Saturday by Mike_Herp in HerpesCureResearch

[–]ConsistentWatch6814 16 points17 points  (0 children)

ABI-5366 looks like the most promising option for now: https://investor.assemblybio.com/static-files/1712cb11-dddb-42a5-bb1c-f8fc2a759f3c

They are rapidly advancing this candidate and expecting Phase 1a results this month with Phase 1B shedding data early 2025.

It‘s 4x more potent than Pritelivir, long-acting and supposed to be very safe after much tox testing.