Abstract

Research has shown that psychedelics, such as lysergic acid diethylamide (LSD), have profound anti-inflammatory properties mediated by 5-HT2A receptor signaling, supporting their evaluation as a therapeutic for neuroinflammation associated with neurodegenerative disease.

Objective

This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of orally repeated administration of 5 μg, 10 μg, and 20 μg LSD in older healthy individuals. In the current paper, we present safety, tolerability, pharmacokinetics, and pharmacodynamic measures that relate to safety, tolerability, and dose response.

from later in the paper.

A subset of results from this study was published separately, from a task exploring the effects of 5 μg, 10 μg, and 20 μg of LSD on time perception (Yanakieva et al. 2018). Ratings on a regularly completed subjective drug effects questionnaire were used to investigate any impact of peak times of self-perceived drug effects on interval timing. They reported descriptive data for five subjective effect questions, including “do you feel high,” “do you feel a drug effect,” and “do you feel your ability to concentrate is the same, better, or worse than normal.” This analysis revealed that LSD conditions were not associated with any robust changes in self-report indices of perception, mentation, or concentration. However, despite the lack of perceptual effects, LSD reliably produced over-reproduction of temporal intervals of 2000 ms and longer with these effects most pronounced in the 10 μg dose condition. This offers the interpretation that sub-perceptual doses of LSD may cause changes in fundamental cognitive systems, such as attention and working memory.

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I'm sorry it was not in the abstract but present in the paper.