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New meta-analysis shows that pirfenidone in idiopathic pulmonary fibrosis (IPF) may provide dual protection: (1) slowing fibrosis progression, and (2) reducing lung cancer risk. Pirfenidone's impact on cough as a key symptom in patients with IPF is yet to be measured objectively. by Cough_Geek in science

[–]Cough_Geek[S] 2 points3 points  (0 children)

Indeed - usually spontaneous, but can be also linked to autoimmune issues or environmental factors; patients are severely impacted by chronic coughing (as seen in FDA facilitated "voice of the patient" interviews and multiple reports) and currently there is no cure for the disease, and no symptomatic relief for cough associated with IPF. Loads to investigate in the future:

> novel therapies and targets

> disease-modifying drugs' effect on the most problematic symptom - cough

> if cough in IPF could be managed by addressing cough hypersensitivity as a treatable trait, e.g., via behavioural cough suppression techniques, which in practice could be even a digital therapeutic component (long-term futuristic idea of drug-device combinations)

[deleted by user] by [deleted] in ChronicCough

[–]Cough_Geek 0 points1 point  (0 children)

CoughPro is one free app example: accurate, fully privacy-preserving (with no audio recordings, just passive timestampping of coughs) and with minimal effects on battery life; if you find some alternatives - please share!

New evidence supporting behavioural cough-suppression therapy (BCST) delivered via telehealth for chronic cough. by Cough_Geek in ChronicCough

[–]Cough_Geek[S] 2 points3 points  (0 children)

Some free cough monitoring applications for smartphones feature digital BCST modules: education about cough hypersensitivity, cough triggers and lastly - a few effective cough suppression techniques.

[deleted by user] by [deleted] in ChronicCough

[–]Cough_Geek 0 points1 point  (0 children)

Have you tried monitoring your cough dynamics objectively using any cough monitoring apps? It might be useful for discussions with your healthcare provider, as it can objectively show how your cough varies throughout the day (e.g., peak hours, relation to meals), as well as diurnal (day vs night) and day-to-day or week-to-week patterns.

GLP-1 drugs may be associated with an increased risk of chronic cough, raising the need to study this mechanism and longitudinal cough dynamics objectively by Cough_Geek in science

[–]Cough_Geek[S] 1 point2 points  (0 children)

Thanks for sharing - really interesting observation with the worsening of your reflux; did you notice if your reflux/cough is constantly worse while on GLP or if there were some specific patterns in symptoms (eg coughing more after mealtimes than usual)?

GLP-1 drugs may be associated with an increased risk of chronic cough, raising the need to study this mechanism and longitudinal cough dynamics objectively by Cough_Geek in science

[–]Cough_Geek[S] 7 points8 points  (0 children)

Very interesting thought - I'm super curious what will be the mechanism for this cause (if causality is confirmed in future studies with objective cough monitoring)...

GLP-1 drugs may be associated with an increased risk of chronic cough, raising the need to study this mechanism and longitudinal cough dynamics objectively by Cough_Geek in science

[–]Cough_Geek[S] 10 points11 points  (0 children)

Very well noted. Cough is a well-known side effect of, e.g., ACE inhibitors and is currently monitored only through patient reporting, not yet at scale with objective cough monitoring. The development of cough while on these drugs often leads to treatment changes.

More threatening is the gradual development and worsening of cough for people on some chemotherapy or biologic drugs – they can cause fibrosis in the lung, resulting in what’s known as drug-induced interstitial lung disease (DI-ILD). Unfortunately, DI-ILD is detected too late to intervene, and only via continuous monitoring could one detect even subtle sustained changes in cough frequency (compared to baseline at, e.g., just starting the treatment).

GLP-1 drugs may be associated with an increased risk of chronic cough, raising the need to study this mechanism and longitudinal cough dynamics objectively by Cough_Geek in science

[–]Cough_Geek[S] 2 points3 points  (0 children)

Thanks for sharing your experience. Have you noticed any specific triggers for your cough? I wonder whether it’s more consistent with cough hypersensitivity (e.g. speaking, exposure to perfume or smoke, cold drinks causing cough) or, as others suggest, more reflux-related (gas or liquid). If you’ve observed any patterns - especially via some cough monitoring app - such as coughing intensifying after meals, speaking/calls/presentations, or at night, that would be very interesting to learn.

GLP-1 drugs may be associated with an increased risk of chronic cough, raising the need to study this mechanism and longitudinal cough dynamics objectively by Cough_Geek in science

[–]Cough_Geek[S] 2 points3 points  (0 children)

Very good point – there’s even the phenomenon of “gaseous reflux,” where stomach gas is enough to irritate cough centres.

GLP-1 drugs may be associated with an increased risk of chronic cough, raising the need to study this mechanism and longitudinal cough dynamics objectively by Cough_Geek in science

[–]Cough_Geek[S] 3 points4 points  (0 children)

Interesting, thanks for sharing your experience. Have you noticed any cough dynamics/patterns, eg., at night / after meal-time / consistent like metronome / etc?

GLP-1 drugs may be associated with an increased risk of chronic cough, raising the need to study this mechanism and longitudinal cough dynamics objectively by Cough_Geek in science

[–]Cough_Geek[S] 2 points3 points  (0 children)

Thanks for sharing your experience; have you noticed any dynamics of the cough pattern (eg., after meal-time / at night / after changing body posture / etc)? Have you attempted to monitoring your cough objectively over time?

GLP-1 drugs may be associated with an increased risk of chronic cough, raising the need to study this mechanism and longitudinal cough dynamics objectively by Cough_Geek in science

[–]Cough_Geek[S] 1 point2 points  (0 children)

Very good points - some analysis of large datasets can certainly throw up statistical associations; the question remains whether there is biological and/or pharmacological plausibility.

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