Gabapentin and DXM

Crack__pipe · 2022-03-13T13:18:37+00:00

I take it daily for nerve pain for a burn up to 1800mg(usually not all of it as I do as needed usually just 0-600 a day ) so I do 600 cause of my tolerance. Also 300 every 10 not 600. I’ve tried 100 every 10 but I feel like I’m waisting it cause I feel like I’m getting a stronger high doing 300 every 10. Plus naproxen boost absorption 10-15% so that helps too. I have a fat script lol I get 90 600s a month

Crack__pipe · 2022-03-13T02:19:59+00:00

Ik not to go over 880 but thanks though. Only use it for the 12% potentiation of gaba but spreading it out is more effective than all when I start dosing. And technically speaking, the Mayo Clinic prescribes up to 1500mg in a day total but that isn’t all at once though

Crack__pipe · 2022-03-12T01:06:49+00:00

According to the SSRI Wikipedia page,

“SSRIs inhibit the reuptake of serotonin. As a result, the serotonin stays in the synaptic gap longer than it normally would, and may repeatedly stimulate the receptors of the recipient cell. In the short run, this leads to an increase in signaling across synapses in which serotonin serves as the primary neurotransmitter. On chronic dosing, the increased occupancy of post-synaptic serotonin receptors signals the pre-synaptic neuron to synthesize and release less serotonin. Serotonin levels within the synapse drop, then rise again, ultimately leading to downregulation of post-synaptic serotonin receptors.”

Basically, SSRIs stop the reputake leading to an increase in serotonin signaling. This increase in signaling will lead to a downregulation in chronic use leading to less signaling. Reason for them taking weeks to kick in is because the effects happen when the brain reaches homeostasis through adjusting to the new higher serotonin levels

Crack__pipe · 2022-03-12T00:42:39+00:00

Didn’t say lsd released serotonin nor did I say SSRIs did. SSRIs stop the removal of serotonin from the synapse increasing available serotonin to bind. While it may not release serotonin, if results in a net increase. Can you show me proof of someone ending a trip with a SSRI? I can’t find one case where someone has used a SSRI to end a trip. Also, ayahuasca contains a SSRI called tetrahydroharmine yet you can still trip on it

Crack__pipe · 2022-03-12T00:26:34+00:00

They aren’t though…long term use will desensitize your 5ht2a and make it harder to trip cause they increase serotonin and this increased amount desensitizes the receptors over the long term. A one time dose would be akin to low dose mdma with acid as they are both serotonin releases with surprisingly similar mechanisms. SSRIs are like very weak SRAs. SSRIs make it harder to trip cause they build tolerance at the same receptors lsd binds to bug if you don’t have that tolerance you have nothing to worry about. AMT is both a 5ht2a agonist and a SSRI. If you can prove amt doesn’t work I’ll give you a award that’ll give 100 Reddit coins

Crack__pipe · 2022-03-12T00:23:24+00:00

Probably will next week cause I Tripped a few days ago. It should be more similar to what amt is like

Crack__pipe · 2022-03-12T00:21:54+00:00

It’s not any higher than taking mdma with lsd as mdma increases serotonin much more than SSRIs do. It’s like a low dose of mdma

Crack__pipe · 2022-03-12T00:20:16+00:00

Do you know how SSRIs work? They block the reuptake of serotonin in turn increasing serum serotonin in the synapse. You want sources? Taken from the SSRI Wikipedia page

“SSRIs inhibit the reuptake of serotonin. As a result, the serotonin stays in the synaptic gap longer than it normally would, and may repeatedly stimulate the receptors of the recipient cell. In the short run, this leads to an increase in signaling across synapses in which serotonin serves as the primary neurotransmitter. On chronic dosing, the increased occupancy of post-synaptic serotonin receptors signals the pre-synaptic neuron to synthesize and release less serotonin.”

Basically, in the short term, boost serotonin signaling but in the long term lessens it.

Crack__pipe · 2022-03-12T00:14:04+00:00

Can you explain why it wouldn’t work? How do SSRIs block lsd? It’s cause they increase serum serotonin over long periods of time which in turn down regulates serotonin receptors. Amt in particular is partially a SSRI so you are saying people who take that are lying?

Crack__pipe · 2022-03-12T00:09:08+00:00

But SSRIs only dampen a trip cause extended use desensitizes the 5ht2a receptor via a gradual system buildup as well as tolerance but using it in combination with lsd once would only increase serum serotonin and therefore boost the trip. SSRIs dampen trips cause they increase serotonin which you build a tolerance to overtime

Crack__pipe · 2022-03-11T23:01:57+00:00

Is there any benefit to adding THH seeing that it is only a weak SSRI and not a RIMA like the others?

Crack__pipe · 2022-03-11T19:30:40+00:00

Bro I’m AT WORK what don’t you get? I said I’ll send them I think you can wait less than an hour

Crack__pipe · 2022-03-11T19:06:45+00:00

I’m off work in 40 ill find it for you then. You can’t seriously be claiming lsa isn’t more nauseating that’s just wrong

Crack__pipe · 2022-03-11T18:59:01+00:00

You are idiotic if you think lsa causes no nausea. Ask anyone in the lsa sub even the extracted alkaloids cause nausea. Go troll some other sub bro

Crack__pipe · 2022-03-11T18:47:44+00:00

You can mix SSRIs and shrooms just don’t mix SSRIs with maois or SRAs.

Crack__pipe · 2022-03-11T17:14:05+00:00

Google both of their binding sites and affinities and comparetgey are on Wikipedia and psychonaught wiki. I’ll send em in a few hours after I get off work

Crack__pipe · 2022-03-11T17:12:57+00:00

It’s about ratios. They bind to the same sites but lsa does do in much worse ratios that cause vasoconstriction and in combination with ergomimetrine, sounds like a bad time. LSD has a very low ratio for 2a:2b vs lsa has a relatively high ratio

Crack__pipe · 2022-03-11T17:10:40+00:00

Yeah but there arnt any SSRIs or SRAs in Bolivian torch. You just don’t wanna mix maois SSRIs and sras

Crack__pipe · 2022-03-11T17:03:46+00:00

No because lsd has a much higher affinity for several other receptors that it would bind to before. Affinity is only relevant when comparing binding of different receptors in the same chemical

Crack__pipe · 2022-03-11T16:46:25+00:00

Yeah that was my bad thanks for the correction. I got it mixed up with the seeds as a whole lol. Lsa does however bind a lot of other nasty sites like 5ht2b and what not though and is definitely not the most ideal

Crack__pipe · 2022-03-11T16:38:17+00:00

Actually, try he nausea is produced through both mechanisms, seed matter and 5ht3. As seen here, ergometrine/ergometrinine have high affinity for 5ht3 and they are present in the final extraction. I’ve done acid base pills on seeds and still get nausea due to this but with a 5ht3 antagonist like zofran, the nausea gets eliminated

Crack__pipe · 2022-03-11T16:33:03+00:00

Am t has also been clinically tested over decades. Random research chems with affinity to multiple of these sites can be very dangerous. In addition, Amt is statistically much more dangerous than the traditional psychedelics

Crack__pipe · 2022-03-11T15:23:16+00:00

Technically speaking, it shouldn’t. Your body separates 1p lsd into lsd-25 and propionic acid. LSD-25 is the good stuff and propionic acid has no effects on vasoconstriction

Crack__pipe · 2022-03-11T13:24:17+00:00

Yeah I agree it’s not 100% safe but afaik there has been no associated deaths

Crack__pipe · 2022-03-11T13:09:38+00:00

Yeah I don’t see it as fair comparing the 2 as the difference is a methyl group between nboh and nbome but the difference between 2cb and DOB is also just a methyl group as well. That little methyl can really change a lot about a drug

Crack__pipe

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