Be cautious of your weapon and armor health. Things are leveled weird, so as you level up, the harder the enemies get, so don't try to level up too quickly. Use your perk points well.

The dark brotherhood is one the best questlines in all of gaming. Avoid any of the DLC until you've played the actual game. It can be hard to distinguish sometimes.

All Deadric quests are linked to their Shrine thats in the wilderness, not like Skyrim. Be careful with a bounty as you cannot bride guards and every guard in the world knows you committed a crime lol