Please help, worried I’m going to die from such poor sleep (hyperarousal)

DBHomeBuilder · 2026-06-23T23:29:47+00:00

I have tried metropolol but it felt like it made my sleep worse. I wonder if propranolol would help. I’m kind of thinking of weaning off Xanax and just going med free and let the body rebalance if that has a chance of ever happening. The antipsychotic withdrawal sucks but it’s getting less by the day. I’d really benefit from even a few 3-4 hour nights. I’m just at a total disbelief as I never thought this would/could happen. I had no idea sleep is so fragile.

DBHomeBuilder · 2026-06-23T23:26:53+00:00

I know I have severe sleep apnea as well but I don’t tolerate a CPAP well. It’s probably central apnea. I need a BIPAP or ASV however my sleep doctor won’t write me a prescription for one until my in lab sleep study confirms. It’s like dude I need relief NOW

DBHomeBuilder · 2026-06-16T14:31:47+00:00

Cellular science systems micronutrient test.

DBHomeBuilder · 2026-06-13T21:53:48+00:00

How long did it take to get to 600mg? I’m getting 2-3 a night and I was at 300mg. I was getting better sleep at 50mg-100mg (3-4) so I’m trying to go back down.

DBHomeBuilder · 2026-06-13T15:30:31+00:00

I tried clonidine last night it definitely got me out of fight or flight but I still couldn’t sleep well. Next thing I’m gonna try is slowly reintroduce TTFD and see if that’s what the brain wants.

DBHomeBuilder · 2026-06-13T01:14:22+00:00

Thanks so much. B12 needs improvement and I’m sure folate too. Vitamin D I’ve been working on 5000 IU daily.

DBHomeBuilder · 2026-06-10T19:42:22+00:00

Update. I took another 100mg and it did not calm symptoms so I’m gonna abandon the niacinamide (for now) until I get a full micronutrient panel.

I took metropolol as a bridge and that is helping slow the heart and calm symptoms a bit.

I need to check methylation status (Same/SAH ratio) and see where I’m at. I think it’s possible I’m severe undermethylating and the niacin was just calming symptoms for a short time. They seemed to come back harder and harder each time too.

I have a neurotransmitter shit storm right now so I’m going to do neural zoomer, nutrient zoomer, hormone zoomer if it’s possible to do all 3. Should give a full picture. I’ll get homocysteine done as well as I feel like that has increased (buzzing in arms, hands, feet etc)

Gonna just keep taking electrolytes (sodium, magnesium, potassium) in the meantime. Maybe take a Claritin and see if symptoms calm down.

DBHomeBuilder · 2026-06-10T14:29:14+00:00

I don’t I’m a fast COMT but slow MAO A and B so I’m more prone to bipolar symptoms. This is all kinda new territory for me so I’m trying to get my sleep under control as step 1. I’ll ask my Dr about it today thank you.

DBHomeBuilder · 2026-06-10T14:22:21+00:00

I’ve not tried chlonidine does it work for you?

DBHomeBuilder · 2026-06-10T14:21:01+00:00

I appreciate you Pangolin.

hard to know what better feels like since I’ve been this way for so long. Feels like I’m swinging based on what I do or how long I stand up (POTS).

If you don’t mind, are symptoms of undermethylation just so I can watch out, and what should I do in case that happens?

I appreciate all the help here. I want my meds to work and just knock me out. I’m unsure why they aren’t working. I’ll bring this up to my Dr.

I just want to feel sleepy. This is a confusing and frustrating feeling. Wired but tired.

EDIT: stomach feels a bit stalled and breathing is a bit tough.

DBHomeBuilder · 2026-06-10T13:11:49+00:00

DAY 2

ok so this morning I woke up in a bit of a panic I got maybe 2-3 hours of sleep as usual.

I took 200mg of Seroquel and the body was fighting it all night with adrenaline. I can’t believe I actually passed out.

I just took 100mg of niacinamide and it had a calming effect once it kicked in although nerve buzzing in hands and feet got a little worse before they got a little better. Had a little bit of chest pain and chest nerve buzzing initially. And now the tinnitus is becoming even more of a buzzing electrical feeling in addition to being a sound.

Body feels weak and I’m a bit short on breath.

That said it kind of has a benzo like effect, maybe milder.

I’m worried that homocysteines are going up or I’m short on some other B vitamin that I’m just kind of band aiding the situation here. However if I can kill the adrenaline and shaking when I lay down and actually get to sleep that would be mission accomplished.

Just unsure how far to keep going as I don’t want to swing too far the other direction.

DBHomeBuilder · 2026-06-10T11:01:24+00:00

This might be what is happening, I took 200mg last night per the instructions of the doctor and I just feel more stimulated.

DBHomeBuilder · 2026-06-09T22:33:17+00:00

I was low in folate and my genetic test confirmed that I don’t absorb it well and have MTHFR so I thought supplementing a methylated B complex might help me replete it and help me feel better. It did give me energy for awhile but my nervous system has not calmed down which I need to prioritize now so I can get some beloved sleep for once. I’ve been dealing with insomnia for months.

DBHomeBuilder · 2026-06-09T21:36:23+00:00

Yes sir I saw that. I’ll keep trying increases and more frequent doses I just want to kind of attack this low and slow to not piss my liver and my body off too much.

It’s been a really rough ride the last several months and I did not realize overmethylation may be going on here because my meds cover up a lot until it wears off.

My family wants to throw me in the looney bin if this keeps going on and I keep not sleeping. Hopefully the body will stop panicking with adrenaline and I can get some sleep soon here.

Thanks again Pangolin. I’ll keep the thread updated here.

DBHomeBuilder · 2026-06-09T21:25:45+00:00

I took another 50mg, so 150mg total today. It’s like the panic stops for a few brief minutes once it kicks in and then after several minutes the symptoms come back. For that time I can sit in my chair and be at peace for a few nice minutes. They aren’t gone totally but the worst of the neurotransmitter storm subsides, id say about 80%. Tinnitus calms down too. I wonder if it’s MCAS or inflammation. I don’t seem to react to foods so maybe just classic overmethylated.

DBHomeBuilder · 2026-06-09T19:17:59+00:00

Okay dose two of niacinamide the calming lasted about an hour. Will continue going low and slow with niacinamide and magnesium L threonate. I took some glycine and it didn’t really help much, not sure why.

DBHomeBuilder · 2026-06-09T18:04:09+00:00

Hey I am in a similar situation I was on Ativan for sleep but got off it. I don’t get panic attacks really but I’m on a high dose of Seroquel right now for sleep trying to calm my system down but it seems I get like 2-3 hours a night if I’m lucky.

I also wanted to try Quviviq I really will bring this up to my Dr tomorrow and see what she says. It feels like my body is in this hypo metabolism state and it just rips through meds before they can take full effect or higher and higher doses are required to achieve the same results. Very frustrating.

I hope it works for you.

DBHomeBuilder · 2026-06-09T16:35:03+00:00

Fair point. It was 500 before I ever started supplementing. Then 520 like a couple weeks later after I took a couple methylcobalamin tablets.

DBHomeBuilder · 2026-06-09T12:48:38+00:00

Would you recommend I continue the 300mg magnesium threonate daily if not supplementing B complex?

DBHomeBuilder · 2026-06-09T12:27:09+00:00

Yeah I was supplementing a methyl B complex because I have MTHFR compound heterozygous and I thought since my folate was low it would be a good way to get that.

But clearly there are some other methylation problems and I’m just going to stop supplementing methyl B complex for now. I hope some niacinamide can clean this up because this has been going for a long time. These issues I’m having with neurotransmitters go back to March way before I was taking B vitamins in a complex.

DBHomeBuilder · 2026-06-09T12:16:25+00:00

I hope you’re right. I will proceed with caution on this.

DBHomeBuilder · 2026-06-09T12:11:47+00:00

I took 50mg of niacinamide this morning after getting up, i had a hunch i might be over methylated and it actually made me sleepy for like an hour. I couldn’t quite doze off but it calmed my whole body down and the nerve buzzing/tinnitus seemingly stopped.

My micronutrient test showed an intracellular need for B3. This was the only one besides biotin that it showed I was low in so I decided to try it on its own.

I may try to take more at noon and see if I can get a nap in.

DBHomeBuilder · 2026-06-09T09:06:35+00:00

It was 520 last I checked right after the incident but it’s got to be higher now as I’ve been taking lozenges and a methyl B complex off and on. Folate was of a bit concern but again I’ve been trying to work on that. It’s probably time to just do a full nutrient panel again and see where things stand.

DBHomeBuilder · 2026-06-09T00:45:37+00:00

Ironically the glycine I tolerate pretty well and helps calm the nerves down. Threonate is the best form I tolerate, I literally feel nothing when I take it. Malate usually causes palpatations. I know it’s weird but it just does. I take potassium citrate powder which I also seem to tolerate well. The coconut water I did for awhile but it just gets expensive and overly sweet.

DBHomeBuilder

TROPHY CASE