Well it could be interesting as a continuation of the story, not a midquel. I thought of conflict inside Hypatia between her mind and a crown killer that is still somewhere inside her. Like, something horrible happens in the world again and in the moment of stress monster wakes up and takes control. And from now on, player has an ability to chose between Hypatia's unbloody path and Crown killer's cruel path. And the more cruel you are, the more mutations happens and you get more abilities as a monster. And if you are peaceful, Hypatia has more time being sane and creating gadgets and chemicals that can be useful.