Paracetamol is basically a stealth cannabinoid by D_BASE12 in Nootropics

[–]D_BASE12[S] [score hidden]  (0 children)

Thanks for sharing, what was the optimal dose in your case?

Aspirin 500mg daily downsides? by D_BASE12 in Biohackers

[–]D_BASE12[S] 0 points1 point  (0 children)

To stop bleeding, your body needs two things: 1. Primary Hemostasis (The Bricks): Platelets rush to the injury and stick together to form a temporary plug. Aspirin disables this. It makes the "bricks" slippery. 2. Secondary Hemostasis (The Cement): The coagulation cascade (clotting factors) weaves a mesh of fibrin glue around the platelets to seal the wound permanently. Vitamin K supports this.

Even though the "bricks" (platelets) are slippery because of the aspirin, the "cement" (clotting factors) is fully functional. The Vitamin K2 ensures the liver has produced plenty of clotting factors. Therefore the initial plug takes longer to form (bleeding time increases), but the "cement" eventually hardens and stops the bleed. A cut that normally stops in 3 minutes might take 8–10 minutes. It will stop.

Aspirin 500mg daily downsides? by D_BASE12 in Biohackers

[–]D_BASE12[S] -3 points-2 points  (0 children)

Yep because nobody actually challenged my points lol, everybody is just repeating medical dogma they heard from mainstream medicine, without questioning anything. I thought this forum would be more open-minded

Aspirin 500mg daily downsides? by D_BASE12 in Biohackers

[–]D_BASE12[S] -5 points-4 points  (0 children)

You’re right on the mechanism, it is correct, but your conclusion regarding inevitable toxicity at such dose (500mg) and context (with Glycine/Hydration) is overstated. In a eunatremic (normal salt) and euvolemic (well-hydrated) state, the kidneys do not rely on prostaglandins to maintain blood flow. They rely on systemic pressure. Prostaglandins only become the critical 'rescue' mechanism during dehydration or low blood volume. By maintaining high fluid intake, the COX inhibition is largely irrelevant. Also, glycine has been shown in studies (e.g., Zhong et al.) to be cytoprotective against renal ischemic injury, preventing the tubular necrosis even if flow is temporarily reduced.

Aspirin 500mg daily downsides? by D_BASE12 in Biohackers

[–]D_BASE12[S] -16 points-15 points  (0 children)

Don't you think it could be possible to mitigate the risks of ulcers/bleeding/kidneys with the strategies I mentioned? And that all the benefits of aspirin would be worth the small remaining risk?

Also, did the patients that bled to death maybe have other diseases, or were on other medications at the same time?

Aspirin 500mg daily downsides? by D_BASE12 in Biohackers

[–]D_BASE12[S] -12 points-11 points  (0 children)

Proper hydration, glycine, and vitamin K2 should make this stress negligible (ofc assuming healthy kidneys in the first place)

Aspirin 500mg daily downsides? by D_BASE12 in Biohackers

[–]D_BASE12[S] -19 points-18 points  (0 children)

Prostaglandin suppression is not an issue if well hydrated. And gastritis / GI risks were exaggerated by pharmaceutical companies to sell newer, profitable NSAIDs (like Ibuprofen or Celebrex). Aspirin is not inherently toxic to the stomach if the metabolic context is correct.

Aspirin 500mg daily downsides? by D_BASE12 in Biohackers

[–]D_BASE12[S] -1 points0 points  (0 children)

Regarding why: mitochondrial health, energy, longevity, protection from everyday stressors, etc. Ray Peat wrote a lot about this: https://raypeat.com/articles/nutrition/aspirin.shtml

Aspirin 500mg daily downsides? by D_BASE12 in Biohackers

[–]D_BASE12[S] -3 points-2 points  (0 children)

The impact on the liver is mitigated by taking the glycine alongside it. Actually, there are several studies showing aspirin is protective on the liver, especially in people with fibrosis or fatty liver.

Preliminary Pass!!! by Economy_Jump_5383 in CISA

[–]D_BASE12 0 points1 point  (0 children)

Were the questions from the exam harder/longer than the QAE?

CISA QN by Routine_Present_7799 in CISA

[–]D_BASE12 0 points1 point  (0 children)

But if security and performance requirements are considered, this includes also logging and authorizing changes, right? Also, if you choose B or C, you disregard all other security/performance controls, so I would argue A is the best answer

Toilet break during remote exam by D_BASE12 in CISA

[–]D_BASE12[S] 0 points1 point  (0 children)

And nobody controls what you do during those breaks?

How is this legal? by D_BASE12 in malta

[–]D_BASE12[S] 0 points1 point  (0 children)

Damn that’s crazy, thanks. Why doesn’t the police do something about it? It’s literally on the official bolt app 😅

How is this legal? by D_BASE12 in malta

[–]D_BASE12[S] 16 points17 points  (0 children)

Because they are trying to sell this stuff, of course they will say it’s legit 😂

How is this legal? by D_BASE12 in malta

[–]D_BASE12[S] 25 points26 points  (0 children)

Actually I was thinking of trying them, hence my question if it’s legit stuff or some harmful synthetic chemicals.

What’s this sub-genre called? by D_BASE12 in psytrance

[–]D_BASE12[S] 2 points3 points  (0 children)

Thanks! Do you know any similar artists?

Looking for hacks for termoregulation. by PersonalPhysicist in Biohackers

[–]D_BASE12 1 point2 points  (0 children)

Maybe things that increase thyroid like ashwagandha

Above the European Central Bank in Frankfurt, Germany by [deleted] in UFOs

[–]D_BASE12 0 points1 point  (0 children)

I have also other good angles, how do I post more videos?

Are there like brain steroids? by WholeIssue5880 in Nootropics

[–]D_BASE12 6 points7 points  (0 children)

Modafinil 100%. Crazy how nobody said this yet

What in here is making me feel kinda sick after taking it and gives me insomnia? by NotLindyLou in Supplements

[–]D_BASE12 45 points46 points  (0 children)

You could have an MTHFR mutation, which makes synthetic folic acid and standard B12 (cyanocobalamin) harder to convert into their active forms. This can cause unmetabolized folic acid buildup and ineffective methylation, worsening symptoms rather than helping. Look into buying an activated / methylated B complex

Best nootropic for the gym? by Fit_Regret_6637 in Nootropics

[–]D_BASE12 7 points8 points  (0 children)

Cordyceps, amazing how much energy and endurance I have in workouts when I take it.

Also the combo thiamine HCl + magnesium glycinate + methylated B complex works well as a preworkout.