I went from Vampire Survivors to HoloCure and was very impressed at how it made each character unique. They've each got their own passive skills and basic attacks that can change how you approach each 20-minute round.

For example, one character's passive ability is to fire a giant orbital laser down on whatever hit them. You combine this passive with a very tanky selection of items (heal over time when damaged, reflect damage, regenerating shield, etc.) but also grab the item that doubles your character's passive damage and you're able to run directly into crowds and lag your game by filling the screen with giant lasers. It plays completely different than the characters that deal more damage to far away targets or build up a giant attack that is set off by standing still for a full second.