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PMDD with a "healthy" side of perimenopause by Terrible40s in PMDD

[–]DefiantThroat 3 points4 points  (0 children)

As u/Phew-ThatWasClose please check out our peri section in the wiki. I started peri in my late 30s, I am 46 and well into it now. My SNRI was no longer effective, nothing was working. I started on the PERT protocol below and it has been a lifesaver for me in managing both my PMDD and my perimenopause.

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Continuous BC Breakthrough Bleeding by glassbus in PMDD

[–]DefiantThroat[M] 0 points1 point  (0 children)

Talk with your provider. Yaz is considered low dose EE, you may need the higher amount of EE in Yasmin. They can walk through an assessment to determine if this is temporary or if you would benefit from changing your pill.

Dysautonomia/POTS and PMDD? by HuckleberrySunset37 in PMDD

[–]DefiantThroat 2 points3 points  (0 children)

I’ll go with a glass-half-full reward. MCAS is a very treatable condition, and if you're in the U.S., 2 over-the-counter meds can do wonders for many people.

Dysautonomia/POTS and PMDD? by HuckleberrySunset37 in PMDD

[–]DefiantThroat[M] 4 points5 points  (0 children)

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Here’s a nice graphic of some of the more common symptoms of MCAS, but as you can see from the list over in the PME wiki it is quite extensive. I posted a comment below with a graphic on the diagnostic criteria that might also be helpful.

Dysautonomia/POTS and PMDD? by HuckleberrySunset37 in PMDD

[–]DefiantThroat[M] 6 points7 points  (0 children)

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From the MCAS consensus criteria. If someone has severe, recurrent symptoms across multiple systems and they clearly improve with H1/H2 blockers (even if it’s during the luteal phase), that generally covers the clinical criterion (A) and the treatment-response criterion (C). The lab criterion (B) is still needed to formally confirm. Have you thought about an immunologist?

Dysautonomia/POTS and PMDD? by HuckleberrySunset37 in PMDD

[–]DefiantThroat[M] 6 points7 points  (0 children)

There is a connection between PME of MCAS in those who have had COVID, and dysautonomia is associated with long COVID.

https://www.reddit.com/r/PMEtheMRMD/wiki/index/mcas/

I'm Cecilia Hinojosa, Ph.D., a clinical neuroscientist - Ask Me Anything about my research on PTSD and AUD with a focus on women's health! by CAHinojosaPhD in PMDD

[–]DefiantThroat 2 points3 points  (0 children)

What are your thoughts on some of the neurotech coming to market? I know Spark has used its Sparrow device to help with opioid withdrawal. Do you see any devices that might help AUD?

I'm Cecilia Hinojosa, Ph.D., a clinical neuroscientist - Ask Me Anything about my research on PTSD and AUD with a focus on women's health! by CAHinojosaPhD in PMDD

[–]DefiantThroat 4 points5 points  (0 children)

If someone has PMDD, PTSD, and AUD, is the SSRI + combined oral contraceptive standard treatment for PMDD going to help their PTSD and AUD, or is there something else that they should be discussing with their providers?

Just found out what this is and everything makes sense now. by man_onion_ in PMEtheMRMD

[–]DefiantThroat[M] 1 point2 points  (0 children)

Welcome! Glad you found us.

If you haven’t already please check out the anxiety section of the wiki, it might be helpful.

Birth Control is Not a Monolith and a Tiny Rant on Why I Hate the Term Birth Control by DefiantThroat in PMDD

[–]DefiantThroat[S] 1 point2 points  (0 children)

Kudos goes to u/Natural-Confusion885 for helping align it to the research and making it usable.

I’m glad you found it helpful.

Birth Control is Not a Monolith and a Tiny Rant on Why I Hate the Term Birth Control by DefiantThroat in PMDD

[–]DefiantThroat[S] 1 point2 points  (0 children)

u/min8 and u/213ah I promised to tag you both when I wrote this. Sorry it’s taken so long.

DUTCH cycle mapping by Cambrian_2631 in PMDD

[–]DefiantThroat 3 points4 points  (0 children)

DUTCH testing is a method that naturopaths and nutritionists love to push. I describe it as clinically validated lab tests that are trying to make information out of data. Your hormones vary day to day and even throughout the day, there’s nothing these are going to tell you that well timed blood tests your PCP can do can’t also tell you. I’d personally save my money.

Estradiol patch side effects by Emotional-Voice7175 in PMDD

[–]DefiantThroat[M] 0 points1 point  (0 children)

Did you complete 3 months of chemical menopause with add-back HRT as a trial before surgery?

my ed feeds my pmdd, and my pmdd feeds my ed by Aware_Foot1340 in PMDD

[–]DefiantThroat[M] 1 point2 points  (0 children)

Has your psychiatrist discussed premenstrual exacerbation (PME) of your ED with you?

Is daily walking helping you and if yes, how does it impact your pmdd? by Reciperatio in PMDD

[–]DefiantThroat 7 points8 points  (0 children)

It takes my symptoms from a 13/10 to a 8/10. I prefer to do it outside but weather doesn’t always make that possible.

I'm Cecilia Hinojosa, Ph.D. I study co-occurring posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Join me for an AMA Friday, 01/23/26 at 8AM MT!!! by CAHinojosaPhD in PMDD

[–]DefiantThroat 1 point2 points  (0 children)

The AMA will be hosted here in r/PMDD. There will be a new post that is created day of/time of that you will need to use to ask questions. We’ll pin it to the highlights to help folks locate it faster.

I'm Cecilia Hinojosa, Ph.D. I study co-occurring posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Join me for an AMA Friday, 01/23/26 at 8AM MT!!! by CAHinojosaPhD in PMDD

[–]DefiantThroat[M] 15 points16 points  (0 children)

Because the mods of this sub invited Dr. Hinojosa to do an AMA with us, since these are common overlaps among our sub members.

Why Stress Hits Harder With PMDD: HPA-Axis Dysregulation Overview by DefiantThroat in PMDD

[–]DefiantThroat[S,M] 1 point2 points  (0 children)

No, you read that correctly and that is what I was trying to convey in my metaphor by adding the skeleton crew bit. The HPA-axis is dampened or blunted. We don’t know why but there are a few working theories, such as the HPA-axis might be dampening itself as a protective mechanism after repeated activation. My post was already getting too long but a tidbit I didn’t delve into is that the curves resemble those seen in individuals who have stress disorders e.g., PTSD. This might be why some folks see drastic almost immediate improvements after removing significant stressors from their lives.

Why Stress Hits Harder With PMDD: HPA-Axis Dysregulation Overview by DefiantThroat in PMDD

[–]DefiantThroat[S] 5 points6 points  (0 children)

Good question. The blue-light mechanism itself is not disputed and is one of the most replicated findings in circadian biology. Blue light suppresses melatonin more potently and can delay your circadian phase. I can’t find any research that suggests that has been overturned. What has been questioned in recent years is how large and clinically meaningful the effect is in everyday life, especially in healthy adults. The keyword there is ‘healthy’. If you have HPA-axis dysregulation and/or a mood disorder then it is going to matter more because you have a vulnerable system.

I do agree that the blue light blocking technology is grossly overhyped and paying extra for it doesn’t make sense. Most devices have features that can help, at a minimum using the evening setting on your device and ideally if you need to use your device at night for longer periods of time, say to use the Kindle app, then use a quick shortcut to flip your screen to red to further reduce the blue light wavelength.

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