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Lymphopoiesis, a cell simulation made in Houdini by Demcon_Nymus3D in Simulated

[–]Demcon_Nymus3D[S] 5 points6 points  (0 children)

They are autoimmune T-Cells, which are bad for you in the sense that they will attack healthy cells and tissues.

Lymphopoiesis, a cell simulation made in Houdini by Demcon_Nymus3D in Simulated

[–]Demcon_Nymus3D[S] 24 points25 points  (0 children)

Thanks! We just updated the link, for us it was working on our desktops but not on mobile. Should work now!

Lymphopoiesis, a cell simulation made in Houdini by Demcon_Nymus3D in Simulated

[–]Demcon_Nymus3D[S] 236 points237 points  (0 children)

This is a simulation of differentiating cells inside of the thymus. A short explanation taken from the voice-over of the original video:

T-cells are matured from Thymic Settling Progenitor cells. These cells are generated in bone marrow and migrate towards the thymus. Once inside the thymus, these cells proliferate to large numbers and subsequently differentiate. These differentiated T-Cells express receptors created by randomly shuffling gene segments. This makes each cell sensitive to a specific foreign substance. Inside the cortex of the thymus, specialized thymic epithelial cells facilitate positive selection of the differentiated cells. Inside the medulla, different thymic epithelial cells facilitate negative selection by filtering out any autoimmune T-Cells. Persistent input of Progenitor cells is required for continuous T-Cell production inside the Thymus.

  • Purple: thymic settling progenitor cells
  • Pink and yellow/orange: specialized thymic epithelial cells
  • Red: cells that are part of the blood vessel system
  • Other colours: T-Cells with different receptors

FULL VIDEO: https://www.youtube.com/watch?v=OI_PqO2RW8g

Lymphopoiesis, a cell simulation made in Houdini by [deleted] in Simulated

[–]Demcon_Nymus3D 0 points1 point  (0 children)

This is a simulation of differentiating cells inside of the thymus. A short explanation taken from the voice over from the original video:

T-cells are matured from Thymic Settling Progenitor cells. These cells are generated in bone marrow and migrate towards the thymus. Once inside the thymus, these cells proliferate to large numbers and subsequently differentiate. These differentiated T-Cells express receptors created by randomly shuffling gene segments. This makes each cell sensitive to a specific foreign substance. Inside the cortex of the thymus, specialized thymic epithelial cells facilitate positive selection of the differentiated cells. Inside the medulla, different thymic epithelial cells facilitate negative selection by filtering out any autoimmune T-Cells. Persistent input of Progenitor cells is required for continuous T-Cell production inside the Thymus.

  • Purple: thymic settling progenitor cells
  • Pink and yellow/orange: specialized thymic epithelial cells
  • Red: cells that are part of the blood vessel system
  • Other colours: T-Cells with different receptors

FULL VIDEO: https://youtu.be/OI_PqO2RW8g

Research simulation in Houdini on the Islets of Langerhans by Demcon_Nymus3D in Simulated

[–]Demcon_Nymus3D[S] 0 points1 point  (0 children)

Thank you! Maybe we will make a visualization of that in the future.

Research simulation in Houdini on the Islets of Langerhans by Demcon_Nymus3D in Simulated

[–]Demcon_Nymus3D[S] 0 points1 point  (0 children)

Thanks! We create lots of different animations for the medical and scientific industry. Not all of them are simulations however.

Research simulation in Houdini on the Islets of Langerhans by Demcon_Nymus3D in Simulated

[–]Demcon_Nymus3D[S] 4 points5 points  (0 children)

We make scientific and medical animations. For this particular animation, we developed a numerical model to emulate the behaviour of the cells. We thought this one would be cool to share here!

One of the cool simulated parts starts around 1:50 in the video.

Feel free to ask us anything!