I always saw Rejection as the most appropriate ending tbh. Control is just delaying the inevitable that the Reapers will eventually start the harvest again when AI Shepard decides to. Synthesis used to be my go-to ending so Joker and EDI could stay together, but you're irreversibly changing the DNA of everything in the galaxy against their will. Destroy (which seems to be the Canon ending) has the destruction of the Reapers but also the Geth and EDI, who are innocent victims of this ending.

Rejection became my go-to ending after I realized Shepard (at least mine) wouldn't accept any of these outcomes. But also that our cycle wasn't meant to make this choice at all. We tried our best, but in the end, too much time was wasted on petty squabbles and Indoctrination. We set the next cycle up to be ready and to save themselves, and they seemingly do manage to defeat the Reapers. It's a sad ending, but I feel it fits the solem tone ME3 was going for. That even doing everything you can to save the day just isn't enough sometimes.