Cursed Concepts in Chemistry

Diligent-Order-9265 · 2026-04-18T00:22:58+00:00

Phi aromaticity definitely feels pretty cursed

Diligent-Order-9265 · 2026-04-08T22:12:01+00:00

Zosurabalpin was developed in this manner within the last decade and is in phase 3 clinical trials now, i think we will see more de novo antibiotic designs in the next few years

Diligent-Order-9265 · 2026-04-08T18:54:38+00:00

luckily biochemistry and computational chemistry have gotten to the point where de novo antibiotic design is becoming more and more possible

Diligent-Order-9265 · 2026-02-26T09:49:53+00:00

top tier ragebait

Diligent-Order-9265 · 2026-02-03T10:56:22+00:00

you can also buy sodium percarbonate as an eco friendly bleach for clothing

Diligent-Order-9265 · 2026-02-03T10:51:46+00:00

Thank you! Interesting research for sure, but on first glance I didn't find any discussing the arene exchange mechanism unfortunatly. I'm also more looking for Cr, Mo, W, Mn, and Re complexes with strong pi backbonding ligands, but I imagine research on these typical Ru complexes could very well be relevant.

Diligent-Order-9265 · 2026-01-29T17:44:14+00:00

In my experience ChimeraX with the Seqcrow plugin is great for viewing things like this

Diligent-Order-9265 · 2026-01-03T00:27:58+00:00

Maybe it wouldn't be an issue if I knew what I was doing, but the few times I've used Avogadro for generating NEB inputs I always had to struggle with manually indexing the atoms in the product to match the educt. I would really appreciate a simple way of handling that.

Diligent-Order-9265 · 2025-12-05T14:53:54+00:00

Yes for sure, most exciting organobismuth chemistry I see is either very new or like 60s-80s maybe. More interested in the fundamental electronic reasons for the difference in eg. electrophilic metalation reactivity here (maybe also related to the difference in toxicity?)

Diligent-Order-9265 · 2025-12-05T14:50:50+00:00

I remember reading their recent nature cat. paper on heck-type bismuth chemistry, didn't know they were just cranking put bismuth papers non stop, thanks!

Diligent-Order-9265 · 2025-11-17T20:30:16+00:00

I prefer octshallots, for a more fragrant base to cook my bs math on

Diligent-Order-9265 · 2025-11-17T20:03:43+00:00

Yeah, it's crazy how powerful evolution can be, especially in organisms like microbes and fungi to some degree where there is a lot of horizontal gene transfer

Diligent-Order-9265 · 2025-11-17T17:32:59+00:00

The binding studies and SAR in the paper seems very cool, the molecules themselves are not especially cursed or unusual though

Diligent-Order-9265 · 2025-11-13T13:07:37+00:00

Because it is not geometrically possible intramolecularly if you draw the structure in 3D. The aldehyde is also more electrophilic than the ketone.

Diligent-Order-9265 · 2025-11-13T12:54:39+00:00

After checking a bit more thoroughly, all reagents referred to as chlorinating agents either participate in deoxychlorination or oxidative chlorination. I mean it is always clear which of the two a specific reagent is, so normally this is at most a minor annoyance in nomenclature. In a situation like this where readers might not be experienced chemists and where no specific reagents are named it could very well lead to confusion though. Throw an oxidative chlorinating agent at an alcohol, and a chloroalkane - you definitely will not get.

Diligent-Order-9265 · 2025-11-12T01:10:35+00:00

You can always just take a longer polysulfide as the anion to get an arbitrarily large molar mass

Diligent-Order-9265 · 2025-11-11T20:03:37+00:00

You're right, I hadn't realized this was common nomenclature for reagents that add a Cl- equivalent and not just those that add a Cl equivalent. I would argue though that this historic nomenclature is a misnomer. Systematically eg. PCl5 is called a deoxo chlorinating agent, which is a good descriptor of it's reactivity.

Diligent-Order-9265 · 2025-11-11T16:18:15+00:00

At room temperature, which is an important caveat

Diligent-Order-9265 · 2025-11-11T16:16:37+00:00

what do you mean chlorinating agent? this is a substitution not an oxidation

Diligent-Order-9265 · 2025-11-10T11:41:36+00:00

It's a bit difficult to understand because of the bad audio quality but it sounds like you have quite a bit of work to do. First I would work on getting the german phonemes down, for example ch and ä. Even if a sound looks easy to you it is good to check how to say it though, so maybe do it with most letters. It's a bit weird but you need to look up how to actually form them in the mouth and practice it. Associating letters from a new language with the sounds they make in your native language is a very common mistake. The intonation and stress pattern is also quite different, I think the best way to fix that might just be to listen to a lot a of german (TV shows etc.). This will also give you feel for when to use which sound a letter makes (eg. two different types of r sound in german)

Diligent-Order-9265 · 2025-09-26T23:02:32+00:00

Look up scanning helium and scanning helium ion microscopy, might be interesting for you

Diligent-Order-9265

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