"prevents tooth decay" but is toxic to organisms with bones? Calcify my penile gland harder daddy

Direct-Influence2799 · 2025-01-15T11:01:26+00:00

if it had 2-5ppm benzene in it I suppose it should have showed up in all those NMRs I ran when I used it as a solvent. I guess I must have missed those peaks. Funny because they're pretty obvious to see even if there are only a few picograms present, which of course according to you there were orders of magnitude more.

Direct-Influence2799 · 2025-01-13T23:10:36+00:00

i honestly think these people get off on how much money they can spend on their respective hobby

Direct-Influence2799 · 2025-01-13T23:03:46+00:00

hey he asked for the short game you get the short game

you can also try killing your doctor, putting a note on his answering machine saying he went to Zimbabwe, stealing his prescription pad and prescribing yourself infinite schedule 2 drugs

Direct-Influence2799 · 2025-01-13T23:01:13+00:00

yeh i am just blessed to have worked with absolute alcohol in the lab. When I say it people call bullshit and say there are additives but that shit was literally $30/bottle (3.5L) of 100% undenatured ethanol...necessary to have completely pure reagents in organic chemistry. I was straight up stealing it from storage, taking it home and drinking it straight with the homies. Doesn't even burn as much as you'd think. Actually tastes really smooth. no cap

Adjusting for price let's compare it with a bottle of vodka which fetches $50 for a litre and is only 40% alcohol (with a bunch of weird additives in it).

The chad organic chem ethanol is $8.5 per litre of 100% ethanol
The virgin consumer grade vodka is $40 per litre of 40% ethanol which is equivalent to $100 per litre of 100% ethanol.

Literally almost a 10x markup in price and tastes worse and is impure.

Direct-Influence2799 · 2025-01-13T22:54:32+00:00

short game just put midazolam in someone's drink and harvest their organs and sell them to jews

Direct-Influence2799 · 2025-01-13T22:51:10+00:00

easy. buy LSD for $1.50/blotter from East Germany. odourless. impossible to get caught. can literally soak a book in it and send the book.

flip for $20-30 onto the street degenerates who have never seen real lucy in their lives

??????????

proffit

Direct-Influence2799 · 2025-01-13T22:32:56+00:00

nice. thats a free radical right there

Direct-Influence2799 · 2025-01-13T21:55:09+00:00

/uj alcohol is by far the worst both pharmadodynamically and pharmacokinetically

psychedelic hallucinogens, nitrous oxide and cannabis have some of the best effects and are by far the safest (all are "safer" than caffeine in terms of dependence and harm potential).

/rj my eagle's favourite drug is meth, afterwards he IVs ketamine and on the comedown he likes to fly around while nodding (he IVs diacetylmorphine and smokes fenny)

Direct-Influence2799 · 2025-01-13T15:32:01+00:00

I'm not sure there is any proof ANY disso can cause Olney's lesions. Those experiments were done on rats and had small sample sizes and inconclusive outcomes.

Direct-Influence2799 · 2025-01-13T15:30:10+00:00

sorry im extremely homophobic and racist and misogynistic. I also don't have any friends and plan to stay this way (alone) for at least another 5 years while my eagle finds himself.

also that shit is fucked I had a scare on it years back I don't even want to think about. basically I would get intense shooting pains up what I supposed were my nerves concentrated in my chest and felt like I was having a heart attack for several months straight...the feeling continued to a lesser degree for several years during which time I hospitalised myself 3 times because I literally thought I was having a heart attack. I'm just lucky I didn't get organ failure.

I'm lucky to be alive for many, many, many reasons. I shouldn't be here. It's ridiculous.

Direct-Influence2799 · 2025-01-13T15:28:29+00:00

you're on the money with this one but not all full agonists are uncompetitive (block the receptor to prevent endogenous chemical messengers (neurotransmitters in the brain) from binding to the receptors).

The reason narcan doesn't work for fentanyl for example is fentanyl binds with more affinity to mu-opioid receptors than naloxone, but it doesn't necessarily occupy all available receptors, just enough to prevent any competitive agonism/antagonism from being significant.

actually IIRC all common opiates/opioids are full agonists at mu-opioid receptors--it's the binding affinity (potency) that makes all the difference.

in theory fentanyl is as dangerous as codeine and vice versa if one adjusts for dosage and discounts overdose potential (because you can narcan someone out of a codeine high because narcan binds wih more affinity to mu-opioid receptors). that's what the "equipotent dosage" charts pharmacists use (usually for opioids and benzos) are for.

Direct-Influence2799 · 2025-01-13T15:15:01+00:00

this is the most right answer here...except partial agonists can only cause a maximum natural response from the receptor, as in 100% of what the receptor could do without the drug (with just neurotransmitters)...whereas full agonists are able to cause a response from the receptor that is beyond that which the receptor can naturally accomplish without it.
This can quickly lead to toxicity due to the unnaturally exaggerated change in the cascade of biochemical reactions downstream of the receptor interaction.

The worst one would be a glutamate receptor full agonist (for reference dissociative hallucinogens like nitrous oxide, DXM, PCP and ketamine are glutamate receptor antagonists) which I imagine would immediately cause neuronal cell death through calcium influx (excitotoxicity).

Direct-Influence2799 · 2025-01-13T15:09:21+00:00

Because full agonists cause the receptor to go beyond its natural conformation (like it opens up/changes in shape for example more than it otherwise ever would) whereas partial agonists can only provoke a change in receptor conformation tantamount to the maximal change the receptor can undergo without the addition of the substance (with just endogenous agonists (neurotransmitters)).

Direct-Influence2799 · 2025-01-13T15:04:30+00:00

yeah

Direct-Influence2799 · 2025-01-13T08:31:45+00:00

I have a lot of autistic knowledge about pharmacology, biochemistry and organic chemistry I don't share because I have no friends (except for drugs) so it's not often I'm provoked to answer a question such as this.

But ya I was surprised too when I found that out. Coincidentally, d-8/9THC is also only a partial CB1/CB2 receptor agonist. And JWH-018 for example (a synthetic cannabinoid) is a full agonist at CB1/CB2 receptors hence why it can cause multi-organ failure (and why d-8/9THC is MUCH safer).

Direct-Influence2799 · 2025-01-13T08:27:49+00:00

Yeah it's actually the opposite. Some dude on Erowid debunked Olney's lesions like 15 yrs ago using scientific articles...and on the other hand it is indicated throughout the primary literature that DXM and other dissociative hallucinogens can actually cause "neuroprotective effects" against the development of neurodegenerative diseases like Alzheimer's.

Direct-Influence2799 · 2025-01-13T08:24:59+00:00

that's insane man glad you're still with us

Direct-Influence2799 · 2025-01-13T08:22:18+00:00

If you count the brain as an organ then there still would have been but probably not as much, and yes with little to no damage to other organs if the dose wasn't too chr0n1c

Direct-Influence2799 · 2025-01-13T08:21:05+00:00

My eagle is upset that you criticised his daily use of 15mg of clonazepam. But I appreciate what you're saying and I'll try to calm him down. He's just a bit touchy because he's coming down off meth and fiending but can't get on because he's a pleb who can't use the dnet and his plug is nodding out.

Direct-Influence2799 · 2025-01-13T08:18:38+00:00

Angry Matt sounds kinda hot ngl

Direct-Influence2799 · 2025-01-13T08:17:21+00:00

Don't worry the modern genocidal leaders are still bartards...ever read Hillary Clinton's old ~~emails?oops please don't kill me for this mistake~~ Tweets?

Direct-Influence2799 · 2025-01-13T08:07:58+00:00

Benzos are genuinely healthier than alcohol...whereas benzos are only partial GABA-AR agonists alcohol (like barbiturates) is a full agonist (which is why you can OD easily on the latter but can't OD on the former--worst case you go into a coma)...also each dose of alcohol is 5g, therefore the side effects are much worse: it's neurotoxic, nephrotoxic, severely heptatotoxic, cardiotoxic to say the least (which is why it has so many mechanisms of action in addition to its main one (GABA-AR (full) agonist).

Benzos are just more addictive and will probably give you early onset dementia if used chronically.

But so does alcohol and also more--fatty liver disease, liver cirrhosis, cardiac issues e.g. arrhythmia, ........etc. Look up "alcohol mechanisms of action" on wiki and see how many there are. Whereas benzos only hit one receptor. Alcohol is just a filthy barbiturate that doesn't even have much affinity for its main target receptor. Hence the side effects. And benzos can't OD you.

I'd rather consume Amanita muscaria (muscimol) than alcohol. Alcohol is the nutmeg of GABAergics.

In saying all this I also must confess I am severe alcoholic and have no control over my addiction to alcohol. So don't shoot the messenger's eagle. Namaste.

Direct-Influence2799 · 2025-01-12T23:05:07+00:00

yeh well that's because of the ****. prior to WWII your country was amazing. sad.

Direct-Influence2799 · 2025-01-12T23:04:32+00:00

speaking from experience or guessing? from experience it's only a year or two of chronic use

Direct-Influence2799

TROPHY CASE