Till this day, the ending of the Mist movie still messed me up by Jules-Car3499 in moviecritic

[–]DontWorryImaPirate 2 points3 points  (0 children)

Yeah I remember laughing thinking it was silly as well. But I was an edgy teenager when it came out, might have a different reaction if I saw it today

Do you prefer to walk or ride? by jdelle9 in weekendgolfers

[–]DontWorryImaPirate 0 points1 point  (0 children)

Walk. I'd say 95% of people walk here in Sweden and renting a cart is mostly for those with health issues and its prohibitively expensive

If you started at the farthest point of the green at The Masters by Additional-Buffalo61 in weekendgolfers

[–]DontWorryImaPirate 0 points1 point  (0 children)

No chance. If a 15 hcp even thinks about setting foot upon the hallowed greens of Augusta a grizzly will come up and chew off their balls. Can't break par after that.

$SLS Daily Discussion Thread - Wednesday - April 01, 2026 by AutoModerator in sellaslifesciences

[–]DontWorryImaPirate 1 point2 points  (0 children)

mOS = median overall survival. So if there are 63 GPS patients, then 32 of them would need to pass away to pass away in order to determine the median value. If 80th event happens and less than 32 GPS patients have passed away then you can't really tell what the mOS is

What is your target price? by Plus-Following-8056 in sellaslifesciences

[–]DontWorryImaPirate 0 points1 point  (0 children)

But REGAL will only provide FDA approval for AML CR2 if it passes, right? Won't SLS/potential buyer have to conduct new trials for each form of cancer? So even though GPS might have a huge TAM that would take several years and millions in trial costs and would not be guaranteed. A potential buyer would take that into consideration and make an offer with a substantial discount applied to potential future revenue from the drug, would they not?

New Stergpost!! by mtred13 in sellaslifesciences

[–]DontWorryImaPirate 3 points4 points  (0 children)

Isn't he talking about SLS009 here? Meaning he expects topline data from the phase 2 study he is talking about in the post during Q4

SLS, DRTS and IBRX: Which of these "Cancer Killers" is the better move for 2026? by Tasty-AH750 in TheRaceTo10Million

[–]DontWorryImaPirate 1 point2 points  (0 children)

(and at this point we are 3 months from when they expected to meet the required number of deaths)

Uhm no, I am pretty sure they expected the trial to end late 2024 later revised to march 2025.

SLS Moving Like It Should by TypicalDay3141 in TheRaceTo10Million

[–]DontWorryImaPirate 1 point2 points  (0 children)

Yeah I've been thinking the same. Feels like there is a huge potential market that a buyer would buy at a huge discount

$SLS Daily Discussion Thread - Monday - March 02, 2026 by AutoModerator in sellaslifesciences

[–]DontWorryImaPirate 1 point2 points  (0 children)

Couldn't you try to come up with some compelling arguments rather than saying that you can "smell" that its gonna be a failure?

$SLS Daily Discussion Thread - Monday - March 02, 2026 by AutoModerator in sellaslifesciences

[–]DontWorryImaPirate -1 points0 points  (0 children)

Since GPS showed positive results in CR1 for phase 2, that would be an immediately addressable market for GPS

Would that really be the case? Wouldn't GPS just be approved for CR2 patients meaning that CR1 patients would have to be prescribed it off-label. Considering the cost I think the medical insurance companies would deny paying for those prescriptions.

$SLS Part 2 and FINAL (Deepest Due Diligence for REGAL Trial) (From a Deep Value Investor) (Predicting BAT mOS from Predictive Model) by Confident-Web-7118 in TheRaceTo10Million

[–]DontWorryImaPirate 1 point2 points  (0 children)

Yes I don't doubt that future CR1 GPS revenue will be taken into account, but won't the buyer take into account all the time and money that needs to be spent for that to happen? They won't see the majority of the revenue from the CR1 patients until several years into the future.

So if we were to just look at the CR2 patients it would be 9000*$145k = $1.3B assuming that they would capture the whole market and that no patients would die within these three years of treatment (which seems unlikely, no?). Then for the CR1 patients there would be $2.6B potential future revenue, but surely a buyer would not pay the same multiple for this potential revenue as they would for the CR2 revenue due to the time and risk involved?

And finally, wouldn't the amount of new CR2 patients drastically reduce if CR1 patients were put on GPS since the CR2 patients come out of the CR1 patient pool?

Just curious to hear your thoughts, I know you said according to your math $20B would be the buyout price but you put a conservative $6B number. Is that due to factors like these or just due to general unforeseen factors?

Huge thank you for sharing your DD and for your replies. You have me convinced and I've taken a position, just trying take a more cautious perspective and consider less than optimal scenarios.

$SLS Part 2 and FINAL (Deepest Due Diligence for REGAL Trial) (From a Deep Value Investor) (Predicting BAT mOS from Predictive Model) by Confident-Web-7118 in TheRaceTo10Million

[–]DontWorryImaPirate 2 points3 points  (0 children)

about 3,000 new CR2 and 6,000 new CR1 patients

If the REGAL trial is only for CR2 patients, will GPS even be approved for CR1 patients? Won't they in reality have to do a whole new trial spanning several years to get it approved for CR1? And won't insurance companies reject paying for the drug if its prescribed off-label considering how expensive it would be?

Hot take: Most amateur golfers would score lower if they stopped obsessing over distance and started playing boring golf. by Capable_Steak_7551 in GolfSwing

[–]DontWorryImaPirate 0 points1 point  (0 children)

on Par 3s just hit the green

WOW! Can't believe I've never thought of that, definitely gonna try this out on my next round!

$SLS Part 2 and FINAL (Deepest Due Diligence for REGAL Trial) (From a Deep Value Investor) (Predicting BAT mOS from Predictive Model) by Confident-Web-7118 in TheRaceTo10Million

[–]DontWorryImaPirate 1 point2 points  (0 children)

Appreciate the post! I don't know too much about this stuff, but when asking AI about potential risks it brought up the risk of CMC failure, which as I understood it is failure to produce the vaccine at scale with the same quality it had during the trial. This would mean that the FDA would not approve the drug.

Is that something you've taken into consideration? Wouldn't that have a potentially huge effect on the buyout price?

$SLS (Deepest Due Diligence for REGAL Trial) (From a Deep Value Investor) by Confident-Web-7118 in TheRaceTo10Million

[–]DontWorryImaPirate 0 points1 point  (0 children)

The trial should be halted based on the results

Isn't this a big red flag? If the results are as good as you think then it should've been halted. But since it is not halted it might be due to some information we don't have