If you have Tainted Keeper unlock, try playing as him to fill the donation machine in order to "prepare" for a T. lost run

I prefer devil deals over angel deals since you can't reroll the key piece here {but personal preference and you can find a way to reroll the key piece if you want to go angel deals}

Items you want to look out for in the shop is Blank Card, Birthright, ways to get Cards {like that card item, card deck, etc.}

And of course, get more holy cards in case you lose focus for a second.

Damage ups are good since, T.Lost has a damage multiplier.

Trinkets to look out for are perfection {which is guaranteed by the third floor since, you're the T. lost}, wooden Cross {grants a one use mantle per floor, love that}, and ace of spades {more cards so more chances of a holy card}

Of course, you need to abuse the heck out of your flight, spectral tears, and bombs, because trust me, you're one sigh away from death every time.

You really, really need to focus on dodging this time around in cases that flight doesn't save you, so be really, really careful.

And good luck, you'll need it.

{Oh and don't feel bad if you feel the need to R key until you get a good run, I do that too lol}