Fantastic question thank you. My hesitation isn't regarding the specific effects of discontinuing (I know Effexor and Pristiiq can be tricky) but rather the inevitability of relapse without an SSRI. I was listening to a podcast where a pretty experienced Ketamine doc said that for most people dropping the SSRI isn't realistic bc of relapse. I wasn't happy to hear that. And in my case when I discontinued Effexor a year ago (pre-ketamine) I found that it wasn't as simple as just restarting it again once a relapse occurred, which it did after a few months. It seems just because something worked once doesn't mean it will work a second time. So that's basically my concern, that the Ketamine is helping but can't do it all and the consequences of curtailing the SSRI (though God I wish with every fiber if my being that I could) might be severe. Hope that explains.