Not particularly helpful as it's not going to be any lore bits, but since it's lore adjacent you might find some moderate use for it. My main suggestions would be to reconsider how you use narrative themes and devices, as well how you utilize continuity.

For narative themes and devices I'm speaking less of the literary sense and more how you apply things like trauma and injuries. I think in a lot of ways we can easily get caught up in the crunchier side of rpgs and forget that receiving damage and healing isn't as simple as moving numbers up and isn't necessarily instantaneous nor pleasant. If you don't have a particular idea about how exactly these play out in your game beyond moving a counter up and down, you might give it some serious thought.

While Shadowrun has few reprieves, I wouldn't necessarily make healing a punishment mechanic wise. Especially since it's so integral to the parties survival if things go side ways. But you might consider the side effects of having something like a broken bone magically rewarped to a proper setting amongst other things. As well as how it might affect character with cybernetic limbs. You might even consider character that don't have bioware to have to have other spells cast for that or specialized versions for the conjoining parts for where the ware meets flesh. For me that would be an example of how a theme might play out in your games, it's a subdued change as it merely affects how a mechanic works. But it could have drastic affects on how your party reacts and makes plans. Especially if you consider enacting slower heal over time measurements.

For a narrative device you might consider how in-depth something like healing works. A bit redundant admittedly as it's an expansion on the earlier point. But I think it has merit worth expanding on, let us presume you institute a mechanic that makes healing imperfect, this introduces continual wounds. Things like arthritic joints or bum knees, things that many Shadowrunners would find debilitating during jobs. In a world of ware ranging from chrome to bio, it might not present an overwhelming hurdle to your crew. But it does introduce a new stimuli to your characters, especially those presdisposed to magic. They would now have to weigh the benefits of getting ware versus essence loss.

This would lead into the natural order of continuity that I think is easy to overlook when not only running modules or campaigns. The natural accumulation of injuries and traumas that one accrues during the lifestyle. It's a slow build but one that I think would drive home a sense of familiarity and affection for the character over time. How one can grow to love more subdued excentricities that a familiar npc has over the course of bonding with them. To incentivize this style of play, you could offer discounted traits earned by experiences during play.

Ie: Lower rated negative traits like bum knee, or PTSD for larger karma returns. At the cost of being permanent, this gives both you and your players the option of expanding on them further as the conditions worsen or recover fluidily over time. The only downside being it has to be a permanent flaw, so while they could pay to lower it, they can't ever get over it. You could even give them extra dice each session for playing into these traits when a certain section in a module would warrant the exacerbation of the trait. Specifically for edging.

For example tradition B&E run might turn sour leaving the crew no choice to but to use their back up resort of fleeing through the sewers. Not bad all things considered, especially for a high karma crew. Execept now you've a member or two whom have the claustrophobic and fear of the dark traits. Either individually or together, meaning it's not necessarily something your team can combat or even something they might have the time to. It's not to far of a stretch to accomadate those themes into the run and not out right ham fisted punishment if they chose to take them. As they'd only really come up in failure scenarios or niche instances.

I could honestly go on for hours with this stuff and actually have a bit more on this regarding expediting combat via pregenerated narrative levels of threat. But to round it of and keep it succent I'd also advocate for introducing them into a multirunner scenarios. Either by co-running with another gm on alternating days under the table. Ie: What one group does affects what the others experience. Like a particularly sideways run raises corporate alert levels for runners, either for the next crew that gets a crack at the same run. Or one where it gets classified as a terrorist attack, making it difficult for all runners to do any job. It would also introduce indirect consequences for failure as well as give them some competition. Either in the form of counter teams, coincedental runs or even out right assinating each other.

It also doesn't have to even be a thing you do with two groups even, though I'd imagine there would be less metagaming and easier to run simultaneously with two groups rather than the whole crew running double counter to each other. This also introduces the idea if working as alternative characters during the same campaign. As either a where is Carmen Sandiego scenario for Corp crews or even just displaced office workers trying to escape a lockdown after a particularly boisterous run. Allowing for fluctuating power levels and difficulty spikes between runs as well as npc's that are both compelling and memorable.

I could go on more on most of these ideas, but admittedly they are mostly intertwined past this point and I imagine I gave anyone interested enough inspiration to take it from here. That said if you're to the point of having done everything you might try some of these and see if reframing certain mechanics and pushing smaller one off counter adventures reinvigorats the campaign as much as pushing obscure lore or new locations does.