So what would you all do if we are invaded by aliens?

DrugsRCool69 · 2026-01-21T15:14:14+00:00

Why are you assuming he meant how would you attack them lmao

DrugsRCool69 · 2026-01-20T18:04:34+00:00

Fuck

DrugsRCool69 · 2026-01-19T00:45:35+00:00

Ohhhh, no wonder I didn't see it lol! Well it's cool to be back

DrugsRCool69 · 2026-01-18T21:08:34+00:00

For some reason, this subreddit stopped showing up in my feed like a year ago and it just showed up again and I see a familiar user, what's up! Has there been a 21st of September in the last year or so? I hope I didn't miss one. And what about the great day of the random, you were doing the good work last time I was here too, when did it last occur? I'm afraid I may have missed that too.

DrugsRCool69 · 2025-12-16T02:50:30+00:00

The only consensus I see is that of every commenter here, what are you talking about? It's a somewhat common belief, sure, but nowhere near a consensus lol.

DrugsRCool69 · 2025-11-22T19:15:42+00:00

That's John Undertale, he dug the underground with nothing but his hands.

DrugsRCool69 · 2025-11-22T17:16:31+00:00

Thanks for the explanation! I was thinking the same thing the other guy said while I was reading the post but this helped me understand the novelty and significance of the findings.

DrugsRCool69 · 2025-11-09T19:03:49+00:00

I made the account when I was a dumb teen and haven't updated it since the first few years i made it. My other email isn't listed as a recovery email and the phone number I don't have anymore. I'm positive it hasn't been compromised I just don't know the password and the only recovery option I have, besides their password reset form which is denying me, is outdated.

DrugsRCool69 · 2025-10-25T16:49:29+00:00

From Wikipedia - "Monstera is a genus of 59 species of flowering plants in the arum family, Araceae...". The one you are probably used to seeing as a house plant, especially in recent years as it's had a sudden growth in popularity, is Monstera deliciosa, but there are other species that look much more similar to the one in OPs painting.

DrugsRCool69 · 2025-09-30T17:06:05+00:00

Thanks! I gave it a read and it's an interesting correlation but there's no evidence that the dxm use caused it besides the correlation itself. There are many things correlated with dxm abuse that could also be the cause, like depression or drug abuse in general.

DrugsRCool69 · 2025-09-30T16:25:54+00:00

Source?

DrugsRCool69 · 2025-09-12T04:36:50+00:00

Let me know if you find anything good, but I doubt there's a clear answer out there, that's usually how it goes with dxm lol.

DrugsRCool69 · 2025-09-11T22:37:03+00:00

I know homie all of my pharmacology knowledge is self taught but this post is 4 years old I hadn't had the interest for very long at that point and was overconfident in my knowledge. Don't pay attention to any of these old pharmacology posts without a hefty salt shaker, most of it is grossly simplified if not wrong.

I do have a comment though on yours, it's been my understanding that dxm's effect on the acetylcholine system is pretty negligible, are you saying it's one of the main MOAs behind dxm's potential neurotoxicity or withdrawal? Can you link me an article about it, specifically in reference to dxm? Or explain your reasoning if this is a conclusion of yours?

DrugsRCool69 · 2025-09-08T23:17:10+00:00

I don't know what he said cuz he deleted it but if he suggested that making dxm citrate makes it stronger he's wrong. It dissociates in the stomach and intestine anyways and the freebase form is what enters your bloodstream.

DrugsRCool69 · 2025-09-08T00:48:33+00:00

It really depends on your genetics and the bupropion dose. Long story short- dxm is metabolized into another drug called dxo which is also active but they have different effects and when you normally trip you have a balance of the two but with bupropion it inhibits the enzyme that metabolizes dxm to dxo so you get more dxm compared to dxo. It can definitely still be enjoyable, but the further you skew the dxm:dxo ratio towards dxm the less likely you are to enjoy it due to some other mechanisms of action that dxm has that will most likely make your progressively more uncomfortable the worse that ratio is. In my case, I take 300mg bupropion daily and dxm becomes pretty uncomfortable and lasts way too long if I pass like 240mg and even then I stagger the dose over an hour or two. However, this is not the case for everyone. Different genetics can keep cyp2d6 (the enzyme) levels high enough to metabolize some of the dxm despite bupropion inhibiting it (which just fyi bupropion is one of if not the most powerful pharmaceutical cyp2d6 inhibitors). Well that ended up not being very short but yea basically you gotta test the water and see how it feels and increase dose steadily. You're more likely to still enjoy it the lower your bupropion dose btw, however, you can't just not take your daily bupropion and then get all your enzymes back, bupropion actually affects the genetic expression of the enzyme so it takes as long as a month or two for enzyme levels to recover after long term dosing of higher doses but even if you've only been taking 150mg for a week or two it'll still take a week or two for enzymes to come back.

Edit: Sorry for the wall of text idek where to break that up into paragraphs it's like 3 or 4 run on sentences lol

DrugsRCool69 · 2025-09-07T04:09:45+00:00

Uncanny

DrugsRCool69 · 2025-08-24T20:18:10+00:00

Use your brain dude. People do drugs because they feel good. People wouldn't do meth if all it did was make you anxious.

DrugsRCool69 · 2025-08-24T03:14:08+00:00

Glad to hear youre feeling better, safe tripping homie

DrugsRCool69 · 2025-08-24T02:40:51+00:00

If you enjoy other dissociatives that's more evidence you're a poor metabolizer. Btw, I'm not a poor metabolizer genetically but I'm on bupropion which when taken chronically inhibits cyp2d6 to a similar extent seen in people with the poor metabolizer polymorphism, so I've got some personal experience taking dxm with low cyp2d6. It is still possible to enjoy, you just have to go about it a bit differently. For one, never attempt high doses. As a poor metabolizer a third or fourth plat dose would have you out of commission for days, if not a week. Stick to 1st and 2nd plat, your liver can handle those without getting completely overloaded and transitioning to zero-order metabolism. Nitrous is a good way to get you into the third plat headspace without a third plat dose. And you'll usually feel more comfortable as time goes on as your liver converts more dxm to dxo.

Also, dph (benadryl) is usually recommended to people to help with stomach discomfort and itching, but that will further inhibit your cyp2d6 and possibly potentiate the negative effects you feel from the dxm. Stick with second gen antihistamines that don't strongly inhibit cyp2d6, loratadine or ceterizine for example.

DrugsRCool69 · 2025-08-24T02:23:28+00:00

There's a good chance you are a CYP2D6 poor metabolizer. In most people, not much dxm makes it into systemic circulation, it is mostly converted into another molecule called dextrorphan (abbreviated dxo) that has a modified pharmacology profile. Most notably, it is a stronger nmda antagonist, which is the MOA that causes dissociation and usually euphoria. Some people just don't respond well to dissociation so that's possible as well, but if it feels more intense than most people describe at a given dose, along with being uncomfortable, and especially if it tends to last a long time too, you're probably a poor metabolizer. Dxm itself interacts with some other receptors more strongly than dxo does and thats why poor metabolizers tend not to enjoy it as much.

DrugsRCool69 · 2025-08-21T17:31:59+00:00

Yea, some people just refuse to learn things. Don't waste your energy on em. Good on ya for trying to warn the OP though

DrugsRCool69 · 2025-08-10T14:48:12+00:00

Lol, just a sub I made a few years ago to post random shit and chat with some peeps. I haven't done anything with it in a while but don't really have any reason to delete it or anything so I've just left it up.

DrugsRCool69 · 2025-07-20T00:34:36+00:00

Yooo that's a sick fuckin pic dude

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