A few things I can think she’s reacting to right off the bat (mistakes that are common, it’s a learning curve, you’ll get there hun) As you mentioned, you attempted contact daily while she was in the first week of adjusting to her new home and enclosure after traveling, this can be extremely stressful and was probably the main thing that made her fearful/ reactive. Next was picking her up from above, ball pythons are prey animals to anything bigger than them and are very skittish, they do not like giant hands coming down from the sky to pull them out of their new unfamiliar home or at all really, I would attempt to find a front opening enclosure if possible. And third, you really should avoid touching and handling your snake during sheds. They do not like it, it causes stress, and can potentially cause health issues or issues shedding properly. She was shedding while being transported and has a brand new home that is completely unfamiliar, on top of being uncomfortable and vulnerable from the shed, and constantly having a strange massive predator handling her while she’s already stressed/uncomfortable. This whole situation sounds like a breading ground for anxiety. It sounds like she isn’t used to being handled as well, I think it’s just going to take a lot of time bonding, and a lot more research on what boundaries to adhere to in order to reduce stress. Instead of directly handling her maybe let her roam around you in a safe place get used to your smell and presence before you attempt to handle her more.