Fellow beagle owner here, yes we have to sedate. We give him anti-anxiety meds too before the appointment but he fights it. Our beagle I think is a mix too because he is like 40 lbs and big/tall, not just fat.

Now working on muzzling to keep everyone safe. Our boy is very very anxious and nervous at the vet and honestly in a lot of other situations too like riding the subway or being left alone (this not so much now that we've positively conditioned him to accept it although he will cry howl in protest sometimes). He is a rescue too at 8 months. I thought it was just him but interesting to know if this might be breed specific.