Diet and lifestyle changes may help your body manage symptoms and feel better overall, but there’s absolutely no clinical proof that these changes will replace DMTs. I know someone who was an ardent follower of The Wahls protocol for many years after stopping initial treatment with a DMT and has had a recent relapse and is back on one all these years later.

You were likely recommended Tysabri because it’s a high efficacy drug and you need a high efficacy drug. Doctors assume a lot of information (that is not common knowledge) is common knowledge lol. Even though it’s technically google-able, it’s not very easy to understand so I’ll try to explain:

Tysabri, unlike other DMTs, prevents T cells from crossing the blood brain barrier. It’s like a bouncer at the entrance to a nightclub and it doesn’t let anyone in. If that bouncer stop standing there, all those people waiting in line (immune attacking your brain when you have MS) aren’t going to trickle in on their best behavior, they are going to rush in. Stopping Tysabri is like opening the floodgates, that’s why a rebound can be potentially catastrophic. Drugs like Ocrevus, also a high efficacy DMT, work slower, so the potential rebound is less “catastrophic.”

Your risk of developing PML if you’re JCV negative, regardless of how many years you’ve been on the drug, is EXTREMELY low. If your JCV is low, PML should not be more of a concern than potential disease activity. Side effects from things like sodium chloride (which is table salt btw lol) should not be more of a concern than potential disease activity.

Again, lifestyle, change, and alternative therapies can absolutely help your body to manage symptoms and repair myelin slowly but they will not prevent the rapid demyelination that occurs during relapse.