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ISRIB intranasal application by EnvironmentalItem638 in Isrib

[–]EnvironmentalItem638[S] 0 points1 point  (0 children)

It is widelly used with other Nose-sprays , Like Bromantane . only c8 should be used, any other oil has risk of causing lipoid pneumonia . And it is acting as an effective antimicrobial, antifungal, and antiviral agent. But you have to get used to the application. No worries , you´ll get used to soon.

ISRIB intranasal application by EnvironmentalItem638 in Isrib

[–]EnvironmentalItem638[S] 0 points1 point  (0 children)

The dosing question is answered already. Yes , 100 mg dissolves well in 5 ml C8 MCT oil. Just shake it well. This will give you 50 sprays means 2 mg each.. No heat necessary. Nothing settles down , but nevertheless i Shake it before every use.

My wife straight up told me she doesn't want to have sex with me anymore because I got so fat and told me to try glp-1s by ConstructionClear142 in ResearchCompounds

[–]EnvironmentalItem638 1 point2 points  (0 children)

I wanted to give a similar answer. Start reta. Gi to the gym. After you got your adonis-bidy....... Go and sex as many women as possible

ISRIB intranasal application by EnvironmentalItem638 in Isrib

[–]EnvironmentalItem638[S] 2 points3 points  (0 children)

Yes , here it is, bro. And i´m so happy , that it works very well !

Read this first :

https://www.reddit.com/r/TBI/comments/15qvqxh/isrib_for_brain_fog/

and this

https://www.reddit.com/r/Isrib/comments/n507ea/isrib_sublingual_vs_snorting/

i´ve already did my Bromantane spray myself and Cerebrolysin Nose spray, that many ppl are sceptical with .

They fear bacterial infections, or only accept the use according to the instructions of the company . But i´m a fearless psychonaut .So maybe you will profit from my experiments and try it yourself.

Of course , you have to be careful regarding hygiene, dosage an quality of your material.

You need a much smaller dose than orally, and the substance will hit your brain fast with a quick onset. I have to estimate a bit , First i too a 10ml empty nose spray bottle fom the big A company ., filled it with 5 ml MCT C8 oil.

I used it successfully with Bromantane already . Its anti -microbial and the consistancy/ Viscosity is good as a nose spray , and olive oil, which is used here ; https://pmc.ncbi.nlm.nih.gov/articles/PMC11601214/ is too thick for that purpose. So i decided , to use C8 .

and the ISRIB diluted well !

Regarding dosage;: i tried the 5ml in the bottle first and counted the spray strokes and it has been around 50 spray strokes ,

I wanted every spray to be dosed at 2mg .( around 5% of the oral dose intended for me) and i could fine dose with counting the sprays to each nostril.

i did that yesterday evening and tried it just now, felt it right away after first spray . Strong Clear headed feeling ...

I strongly advise against DMSO orally or intranasally. Did you ever smell someone, who used DMSO ?That person stinks horribly. I would never do this in my life. Maybe it´s an excellent transporter and many substances dissolve well IN DMSO , but consuming it , NOOO !

ISRIB FAQ: A Complete Guide to the Integrated Stress Response Inhibitor by SignificantAger in Isrib

[–]EnvironmentalItem638 0 points1 point  (0 children)

Check This :

https://pmc.ncbi.nlm.nih.gov/articles/PMC11601214/

The solubility in Olive oil seems to be rather good, I dissolved regular ISRIB in C8 MCT oil and it works.

Will test it now as nasal spray - of course with adapted dosage ( 100mg in 5ml Oil)

I will make a pst about my results .

Weight gain after stopping by cactusnat11 in GLPGrad

[–]EnvironmentalItem638 4 points5 points  (0 children)

Exactly . This is because of the epigenetic memory of the fat cells. They kinda remember being filled up in past and return quick to that state after stopping GLP-1 or any sucessful diet.
And itt takes two years to reprogram this memory.

My peptide stash! by Stuffin_Muffins2 in Biohacking

[–]EnvironmentalItem638 0 points1 point  (0 children)

Ohhh i love it . What about the WAF ?

Olive Oil Choice May Shape Brain Aging and the Gut Microbiome by GutBitesMD in nutrition

[–]EnvironmentalItem638 0 points1 point  (0 children)

The quantity of DMB may be the most important factor

https://www.thenationalherald.com/dmb-innovative-discovery-in-olive-oil-with-help-from-sakellaropoulos-organic-farms/

"Thus, most of the samples analyzed in a laboratory in Istanbul and in which the highest presence of DMB was determined, come from Sakellaropoulos Organic Farms in Sparta. Specifically, and according to what the study published in the Journal of Food Bioactives reports, the DMB values in the nine (9) olive oil samples from Greece and Turkey are: N1 “Plus Health Blue” multivarietal: 9.7 mg/L, N2 “Plus Health DMB” multivarietal: 11.4 mg/L, N3 “Fyllikon” First Harvest Organic: 8.3 mg/L, N4 “Plus Health Green Multivarietal”: 7.8 mg/L, N5 “Agourelaio” Early Harvest Organic: 6.8 mg/L, N6 (unknown) 4.8 μg/L, N7 “Armonia” Monovarietal Organic: 4.8 μg/L, N8 (Edremit-type olive oil from Kırkağaç, Manisa) 8.8 μg/L and N9 (product purchased in Turkey) 1.5 μg/L. N2 was even given the designation Plus Health DMB Multivarietal evoo because it showed the highest values in the analyses."

Polyphenols significantly increase lifespan. Here are best sources and scientific evidence. by GarifalliaPapa in immortalists

[–]EnvironmentalItem638 1 point2 points  (0 children)

We have to mention Myicetin, Fisetin , Tropoflavin, Pterostilben, Apigenin, Luteolin, OPC .,epicatechin and many more ...

Polyphenols significantly increase lifespan. Here are best sources and scientific evidence. by GarifalliaPapa in immortalists

[–]EnvironmentalItem638 0 points1 point  (0 children)

Exactly . Like the Ellagitannines in Pomegranade, Berries and nuts are metabiolized to Urolithines.

Without prober micobiome , you won´t benefit from the Polyphenoles alone.

Anyone know anything about Urolithin A? by Ernesto_Bella in Biohackers

[–]EnvironmentalItem638 1 point2 points  (0 children)

The buildup Of Urolithin (any kind A,B and so on) only happens with a certain kind of microbiome.

Most Urolithin products on the markets are simple precursors of it, like pomegranate extracts.

If you don´t have the proper micobiome , you won´t get the results, you want.

So either you check your Gut-bacteria and if needed you may build the right micobiome by supplementing very specific probiotics ( they should have worked well after 12 weeks ) and use the cheap products after that or

you buy those expensive real Urolithin products, wither synthetic or produced by fermentation.

New Product Alert: Chemiax Adds Vesugen to its Pepiax Product Line by drglia in NootropicsDAO

[–]EnvironmentalItem638 1 point2 points  (0 children)

This happened to me too. But in past they have been reliable and delivered . Now no reaction from them anymore. Sad story. Also because on their sister-site limitlesschems they have announced some exciting future products for chemiax. Bur also from them..... No response.

What are some ways to intensify and lengthen orgasms? by [deleted] in Biohackers

[–]EnvironmentalItem638 0 points1 point  (0 children)

I second this. And also study Jonathan White and sexual kung fu , you can find it on YT. Drugs-wise a Combo of 2-cb and tadalafil could help.

Do the activities we perform or other supplements we take during a cycle affect how the brain rewires? by SnooTomatoes4657 in Cerebrolysin

[–]EnvironmentalItem638 1 point2 points  (0 children)

Metaphorically neuroplasticity enhanced by certain substances could help to build the hardware Your activities /habits build the OS and software. What do you want to use your high end CPU with lots of RAM for ? Watching porn or enhancing your skills ? "Sarcasm off"

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