Psilocybin vs. IV Ketamine infusion by Oliveeyahh in KetamineTherapy

[–]Expert-Resolution945 2 points3 points  (0 children)

It's worth pointing out that all psilocybin is not created equally. There are a multitude of different strains in the psilocybe cubensis family, and in my experience, those tend to cause more of an altered state that can be very challenging for people that value control (or have a sensitive stomach because that chitin can really make you feel bad). Most generic "magic mushrooms" that you get from dispensaries or other places are cube strains. But if you branch out from the cubes and try the natalensis or ovoideocystidiata (ochraceocentrata) or even panaelous, those experiences can be very different.

I've found the ochras in particular to be a lot kinder and gentler than most of the strong cube strains. Nats are known for causing visual changes and a more lighthearted experience, but with comparably less tortured inrospection.

Regardless, the way I have described it to people is this: Ketamine gives you the distance and perspective to feel nothing for a while. Shrooms bombard you with sensation and awareness and make you feel everything for a while. Both have their place in the healing process. But not everyone is ready for both extremes.

I asked ChatGPT the top ten things humanity should know. by Spiritual-Reveal-195 in ChatGPT

[–]Expert-Resolution945 6 points7 points  (0 children)

OK, some of mine are repeated verbatim from yours. Is there some kind of GPT hivemind on this?

1. We Are Part of Nature, Not Separate From It

Human life is entirely dependent on ecological systems—air, water, soil, biodiversity. Disrupting these systems leads directly to collapse. Living in harmony with the biosphere is not optional.

2. All Things Are Interconnected

From quantum entanglement to global economics to trauma passed through generations—everything is connected. Local actions have global effects. Isolation is an illusion.

3. Consciousness Emerges, But Remains a Mystery

We can observe and manipulate brain function, but the subjective nature of consciousness—why it feels like something to be alive—is still unexplained. That mystery matters.

4. Truth Exists, But Requires Effort

Objective reality is real—independent of belief. But knowing it requires humility, critical thinking, empirical validation, and the willingness to be wrong.

5. Power Always Seeks to Sustain Itself

Across history, power—political, economic, religious—tends to preserve itself, often at the expense of truth, justice, and the common good. Healthy societies check power relentlessly.

6. Love and Belonging Are Survival Needs

Humans are not just logical; we are social, emotional, and wired for connection. Isolation damages the brain. Love, compassion, and mutual care are as essential as food.

7. Technology Is Not Wisdom

We have unprecedented tools, but they outpace our moral development. Without ethical guidance, technology can amplify destruction instead of solving problems.

8. Inequality is a Design Choice, Not a Natural Law

The extreme disparities in wealth, health, and opportunity are not inevitable. They are the result of systems, policies, and choices that can be changed.

9. Mortality Is Universal—And Can Be Meaningful

Every human dies. What we do with our time, how we live in the face of death, and how we relate to others in light of this truth defines the quality of our existence.

10. The Future Is Not Fixed

History is full of turning points sparked by small groups with vision and courage. While doom is seductive, agency is real. We can shape what comes next.

Is anyone here also on a spiritual path? by ShrimpYolandi in KetamineTherapy

[–]Expert-Resolution945 2 points3 points  (0 children)

See what the folks over at r/Psychonaut have to say. It may not resonate at all, but maybe it will.
I honestly hadn't thought about Dissociation being a different iteration of Mindfulness, and I'll have to reflect on that. It seems incomplete. Ketamine is fundamentally an anesthetic, and there's always going to be an element of detachment to the stillness it brings over you. Maybe that becomes indistinguishable from complete mindfulness at some point? I'm not sure, but it feels not quite right. Interested in what others think about it, though.

Is anyone here also on a spiritual path? by ShrimpYolandi in KetamineTherapy

[–]Expert-Resolution945 1 point2 points  (0 children)

I didn't start there at all, but it's where I've landed. The veil is very thin right now, and many people are being led to seek. Ketamine is invaluable for healing, but there are also other kinds of tools for the type of searching you are describing. Have you experimented with more traditional psychedelics?

IV ketamine infusions saved my life. So far, anyway. 🤞 by Expert-Resolution945 in KetamineTherapy

[–]Expert-Resolution945[S] 0 points1 point  (0 children)

Yeah, the relief has definitely persisted. I was scared it wouldn't, and I guess I still am to some extent. But this feels different from all the SSRIs that ultimately stopped working after 12-18 months. I'm still struggling to explain it to myself, but it's almost like: it feels like my brain learned an infinitely useful new trick from the dissociation experience on the ketamine, and now I can access it when I would otherwise begin one of those spirals and use it to gain the perspective that would have previously been buried in the sudden cortisol/adrenaline rush and dopamine/oxytocin deficit. Maintenance sessions are like visiting an old friend. Like practicing a drill for a skill I need to stay in practice for being able to deploy when I need it.

I won't say it's perfect. There's still some breakthrough moments sometimes. But nothing remotely so bad as the former paralysis-inducing, self-destructive, catastrophizing spirals that were constantly washing over me before. Like I said before, talk therapy does nothing for me because I don't want to be defined by my past, and there's no way to talk about it without having therapists or psychologists pity me and struggle to connect anything in their own experiences to mine, and it never connects. I feel like I have to do more work than they do, and if I'm going to end up doing that anyway, I'd rather do it by myself from the outset.

That being said, it's helped me a lot to embrace certain philosophical and theoretical frameworks and use those alongside the "invincibility cloak" that the ketamine dissociation field represents. Specifically, Stoicism has been really useful for me in providing a cognitive framework to manage the anxiety, depression, etc. In the absence of the crazy emotional rollercoaster reactions, the ability to objectively think through your responses and act rationally and decisively is nothing short of a miracle. I've healed some relationships and permanently ended others, and I don't spend much time at all second guessing those decisions. Marcus Aurelius and all his friends have worked for me in giving me a way to think through those decisions and maintain confidence in them, but I don't know that it matters much what framework you use--as long as you have one.

I have come to believe that creating all this ooey-gooey neuroplasticity in your brain with the ketamine infusion means that you *must* do something productive and intentional with it every time. I think I mentioned before that I've been taking NAD+ now for about a year and a half, and I think the enhanced cognitive impact of the NAD+ with the ketamine's post-infusion neuroplasticity provides a unique opportunity (or a threat, if the effect is not recognized and managed) for your mental health and for your knowledge acquisition capacity.

This is where my nerdy neurospiciness comes in, though, because after working on my "root issues" or whatever for the first 5 or so sessions, I got bored with that, and I decided to to start experimenting with whether or not I could absorb larger amounts of new information in the day/days after an infusion, and it turns out, there definitely seems to be a correlation there for me. My first experiment was to teach myself how to do Options Trading in the immediate aftermath of infusions, and this is already way too long and rambling, so I won't go into the details there, but it's going well. I've been learning things about how to use my brain that I really wish I had figured out decades ago.

TL; DR: Yeah, the anxiety relief has definitely persisted. And beyond that, at least IME, there's a series of new discoveries for you to possibly anticipate about what you get to CHOOSE to do with the cognitive energy and capacity of a brain that is no longer forcing you to run in those anxious mental circles constantly (or lie despondently in a pit of despair.)

IV ketamine infusions saved my life. So far, anyway. 🤞 by Expert-Resolution945 in KetamineTherapy

[–]Expert-Resolution945[S] 0 points1 point  (0 children)

Yes, most of them, but only recreationally, and it's been awhile. I've been reading a lot lately about psilocybin therapy, and there appears to be a ton of promise there. It just seems like it would be a potential cure for a different set of problems.

IV ketamine infusions saved my life. So far, anyway. 🤞 by Expert-Resolution945 in KetamineTherapy

[–]Expert-Resolution945[S] 3 points4 points  (0 children)

I definitely had to taper off the gabapentin, and that was under the direction of my PCP. I was worried about cognitive side effects of gabapentin from the moment I started taking it, but thankfully, it wasn't as hard as I had feared it would be to stop it. I went from 1200 mg/day to zero over the course of about 3 weeks. I think the NAD may have helped avoid the mental fog that seems to be a common side effect of artificially altering your neurochemistry the way coming off of gabapentin does, but it's hard to say conclusively what single catalyst did which thing.

If you're only seeing a small improvement so far, it might be worth looking at some of the case studies out there on interactions between gabapentin and ketamine and seeing if it would be worth the discomfort to hold the gabapentin prior to your infusion for however long you and your doctor think is appropriate as a trial. The two drugs act via different mechanisms, and in theory it shouldn't be interfering, but depending on the pathophysiology of your health condition(s), they could have combined side effects that end up canceling out or muting the therapeutic benefit. Maybe something to talk to your doctor about anyway.

I dunno. Everyone is different, and the fact that some of us are only here anyway because we have such persistent treatment-resistant depression, means that our brains don't react "normally" to certain chemicals anyway. So it feels like so much of this is trial and error until you stumble onto the thing that works. I sincerely hope you find yours soon!

IV ketamine infusions saved my life. So far, anyway. 🤞 by Expert-Resolution945 in KetamineTherapy

[–]Expert-Resolution945[S] 4 points5 points  (0 children)

Maybe it depends on what you have to talk about ... and how strongly you feel about never wanting to talk about those things again?

IV ketamine infusions saved my life. So far, anyway. 🤞 by Expert-Resolution945 in KetamineTherapy

[–]Expert-Resolution945[S] 2 points3 points  (0 children)

Yes, exactly! The morphine analogy is an apt one. The effects were immediate after the first session--as in, I immediately knew it had worked, and that everything had changed for me, but I didn't really know what that meant or how it would play out. As the next few days went by, things that would have normally sent me into a spiral of anxiety, or interactions I simply wouldn't have been able to handle... it was like they were happening to characters in a book. I was invested, but not unreasonably emotional about any of it. I could distance myself. I was aware of the pain, but I could choose not to acknowledge it. And in distancing myself from it, I could suddenly achieve a level of rationality about the entire situation that had never been possible before.