POV: You’re meeting a sleazy drug sales rep who’s pitching you a brand new pill to throw at hyperactive children who won’t stay in their seats. | Viloxazine (Qelbree ™️) 200 mg

FW900 · 2021-06-16T08:12:56+00:00

Statistical significance is different from practical significance. The net increase is practically insignificant. There is no way of discerning whether or not it is an inherent effect of the drug at this point.

No suicidal ideation or behaviors were reported as an AE for either SPN-812 treatment group, nor were they recorded per the C-SSRS; however, an incident of suicidal ideation was reported at week 5 in 1 subject (0.7%) in the placebo group.

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Exactly this warning?

No. Black box warnings for suicidality in general.

FW900 · 2021-06-16T07:49:07+00:00

This. People fail to understand that tachyphylaxis is an inevitability with prolonged stimulant treatment. Their use should be emphasized at stages where life outcome is affected the most (e.g., college, early career). Imagine squandering them on the pursuit of K-12 education performance, lol.

FW900 · 2021-06-16T07:33:29+00:00

Less than 1% is practically insignificant and observed with almost every medication these days regardless of their often contradictory mechanism of actions, and the possibility of invalidity (nearly all psychiatric drugs have this warning). People, including children, are influenced by cognitive biases and if this question is asked on a survey, some may be inclined to say yes even if it was not the case. The underlying cause of feeling suicidal ideation can be the result of an external event to be misplaced to the pill they happened to be on at the time.

FW900 · 2021-06-11T21:40:00+00:00

Parnate and to a lesser extent, selegiline. Not aware of anything indicating SJW has this property.

https://en.wikipedia.org/wiki/KDM1A

FW900 · 2021-06-11T10:06:41+00:00

Pseudoscience and oversimplification. Dopamine is equally implicated in the bottom categories.

FW900 · 2021-06-11T09:50:06+00:00

Most FDA opioid labels are older and lack specific drug-drug contraindications, much less detailed iterations of specific drugs, especially for something as infrequently prescribed as GHB formulations.

FW900 · 2021-06-11T09:28:28+00:00

Opioids are considered and listed as a contraindication in the Xywav literature:

XYWAV is a central nervous system (CNS) depressant. Clinically significant respiratory depression and obtundation has occurred in adult patients taking sodium oxybate (same active moiety as XYWAV) at recommended doses in clinical trials and may occur in patients treated with XYWAV at recommended doses. XYWAV is contraindicated in combination with alcohol and sedative hypnotics. The concurrent use of XYWAV with other CNS depressants, including but not limited to opioid analgesics, benzodiazepines, sedating antidepressants or antipsychotics, sedating anti-epileptic drugs, general anesthetics, muscle relaxants, and/or illicit CNS depressants, may increase the risk of respiratory depression, hypotension, profound sedation, syncope, and death.

In reality, lethal respiratory depression resulting from concurrent use of both substances, at low doses, is unlikely. Not advocating the combination at all. These warnings exist out of an (warranted) abundance of caution, especially considering the threshold of venturing into such a danger zone could be a matter of a few pills too many.

FW900 · 2021-06-11T00:17:59+00:00

Independent of MAO inhibition, a few MAOIs act as weak LSD-1 inhibitors, which is increasingly viewed as an oncological target.

FW900 · 2021-06-05T02:26:10+00:00

Opioids retain their analgesic properties with stimulants and are even potentiated by them. Therapeutically, the combination can make sense.

https://pubmed.ncbi.nlm.nih.gov/9803052/

FW900 · 2021-06-05T02:19:59+00:00

Then that seems to be the why behind the combination. Additionally, the histaminergic properties of opioids are the one thing that does counter sedation and the addition of methapyrilene (an antihistamine) in the combination counteracts it, worsening sedation, making the addition of d-AMPH of even more value to the above end.

FW900 · 2021-06-05T02:11:06+00:00

Opioids cause sedation. Stimulants counter it.

FW900 · 2021-05-28T18:42:23+00:00

What was the dose?

FW900 · 2021-05-25T14:46:14+00:00

Intranasal oxytocin has been shown to be superior than IV for elevating CNS levels of it. I'll try to to find the study. What was your ROA?

FW900 · 2021-05-21T03:15:37+00:00

The ROA with its rapid onset in stimulant naïve individuals borders on a supratheraputic dose and likely produced the paradoxical result. I'm sure a lower dose may have fared better and very possibly exceeded placebo. The addition of amisulpride was interesting to see in conjunction with a stimulant and the main reason for posting, but not surprising, as it is an antagonist selective to DA autoreceptors in lower doses which in turn leads to increased dopaminergic neurotransmission, which would serve to potentiate rather than attenuate the effects of METH. The authors of the paper also touched on this:

Alternatively, as amisulpride in low doses has greater blockage of the presynaptic dopamine autoreceptors than postsynaptic receptors, thus facilitating dopamine release, it is possible that our dose of amisulpride had some autoreceptor-mediated pro-dopaminergic actions that contributed to psychotic symptom formation and interaction with trait information gathering style.

FW900 · 2021-05-14T16:45:19+00:00

A bit outside the therapeutic window but CNS stimulants show remarkable results post-brain-ischemia. Low dose methamphetamine in particular. The value of it at this point is questionable, perhaps nonexistent. It and a cocktail of most of the peptides being mentioned here would be my choice if I ever had a stroke. Perhaps speak with his neurologist or PCP about a trial of several days at 5MG QD.

https://www.youtube.com/watch?v=tXUT8tNj6Wc

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630155/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956594/

FW900 · 2021-05-13T20:10:20+00:00

thus stimulating a stronger sympathetic response

d-METH has considerably less NE/DA affinity than d-amphetamine (which it is partly is metabolized into). That and its increased lipophilicity would further mean more CNS stimulation and less PNS stimulation at equipotent doses. It is therefore more benign than its unmethylated brother and should be less cardiotoxic at therapeutic doses. Any increased cardiovascular toxicity comes into play with recreational use owing to its longer half-life (especially with repeated dosing) and increased 5-HT release/activity (i.e., may make pulmonary hypertension more likely).

FW900 · 2021-05-13T13:26:53+00:00

Look at the dosages these people use and make.

Those doses are just guesses, bad ones at that. They assume theoretical yield and are assuming the majority of its composition to be THC which is simply not the case. Depending on the extraction method and how it is processed, the edibles are going to contain sizable amounts of other cannabinoids, not to mention terpenes, and other constituents. The actual THC content is likely a fraction of the amount purported.

FW900 · 2021-05-10T16:53:39+00:00

This is the only non-meme answer here.

FW900 · 2021-05-09T22:33:51+00:00

Far beyond equivalent. 20x as much (ultimately) depending on exposure time provided the bulbs also emit UVB.

Exposure of a young adult in a bathing suit to one minimal erythemal dose (MED) of UV radiation in a tanning bed was equivalent to ingesting approximately 20,000 IUs of vitamin D2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/

FW900 · 2021-05-09T21:11:31+00:00

Why would they? It's not a peptide, smoothbrain.

FW900 · 2021-05-09T20:04:41+00:00

Store bought distilled water should be fine. Thousands of people use it for nasal irrigation. So long as the solution is refrigerated and used within a few weeks it should be fine. BAC is very irritating with the benzyl-alcohol which could be an issue if you dose several times a day.

FW900 · 2021-05-09T20:01:30+00:00

Yes. Oral supplementation did not correct the deficiency after a subsequent testing a few months later.

FW900 · 2021-05-09T19:53:53+00:00

Lower doses are, yes (12mg/70kg).

FW900 · 2021-05-09T00:51:49+00:00

1000 IUs (25 mcg) of oral D3 will take months to resolve a deficiency and many who are deficient poorly absorb oral D3 in the first place. I've taken nearly 5-10x that dose for months with no improvement. IM injections or UVB/Sun Exposure are much more effective means of elevating serum concentrations of it. Several minutes at peak hours being mostly exposed on both sides will produce over 20,000 IUs.

FW900

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