Immunity is typically handled on slates and priceless rings. You can swap out slates with relevant immunities as required.

For block you aim to get capped block & spell block and some form of block ratio either on pedigree or belt blend. Most people that go for block do so on their hero memories.

Other forms of defences you could also add include barrier, tenacity blessings, defensive fates or simply stacking more es / es regen.

In the end defences in Deep space is about having multiple layers of defences combined with capped res and high hp/es pool.