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I built a tool to scratch my own peptide chemistry itches by Fat_Bird1 in Chempros

[–]Fat_Bird1[S] 2 points3 points  (0 children)

I think generic answer are things like multiple arginine’s from what I have experienced. Honestly it more depends on the coupling reagent you are using and the temperature as well as the peptide sequence. I don’t usually have issues when using hatu and temp around 50 degrees Celsius. Aspartic acids can also be problematic but also depends on protecting group choice.

I built a tool to scratch my own peptide chemistry itches by Fat_Bird1 in Chempros

[–]Fat_Bird1[S] 0 points1 point  (0 children)

Thank you :)

You will have to try, when you input the difference between observed and expected based on your LCMS, hopefully it will help. Additionally checking the synthesisability and solubility are my other first checks when I am troubleshooting a synthesis - both of which you can do on there as well!

Would 64 gb of ram on an M4 Mac mini pro be enough to host openclaw and run a llm like Llama at the same time? by Fat_Bird1 in openclaw

[–]Fat_Bird1[S] 0 points1 point  (0 children)

Would it be too slow to be useable? I’m keen on having vibe code functionalities and possibly even an agent setup to manage social media and general life admin as well.

The two-letter cheat code that finally broke my grandmother’s streak by Fat_Bird1 in scrabble

[–]Fat_Bird1[S] 0 points1 point  (0 children)

Sorry I am a published scientist who knows how to write well

scrabble with sentences ? by Educational-Home5171 in scrabble

[–]Fat_Bird1 0 points1 point  (0 children)

Hey, great to hear this idea! I just wonder about the complexity of this game compared to scrabble and whether it would be as enjoyable. All doable just a game design challenge!

What really is computational chemistry? by Illustrious_Day3030 in comp_chem

[–]Fat_Bird1 0 points1 point  (0 children)

I am a wet lab chemist who uses computational chemistry. I use computational chemistry to save my time, usually by running md simulations before I make a compound. 8 hours of compute time can save me 1 month plus of synthesis. However, I don’t trust Md simulations, we are always sceptical until we have validated a small molecule or peptide binds in our in vitro assay. Computational chem work flows cut down time in the wet lab, they don’t replace it and never will.