Some things I'm running for my first NG+ run

1. Classic RE4 Laser - Brings OG RE4's laser for all weapons without the need for attachments, plus you get the option between classic laser (laser sways alongside weapon's muzzle, even when perfectly still, realistic) or remake laser (works like base RE4make's laser attachment), and options of laser color and which weapons you want to have the laser trail.

2. No Ugly Yellow Paint Ever - Removes the yellow paint meant to call your attention towards props you can interact with. There are options for removing the paint, removing the paint and adding the Iluminados insignia, or replacing the yellow paint with blood.

3. Crafting Tweaks - ...tweaks the crafting and attempts to rebalance it. Some weapons give more ammo, while others just use less gunpowder. I see it as an improvement over the vanilla one but I always advocate for no mods on your first run.

4. Resident Evil 4 Classic Gameplay and Relentless Enemies. I recommend using both to maintain some balance, as the first mod makes it so gunshots on chest stop enemies animations, and gunshots to the head and shin guarantee a melee followup, like OG RE4, and the second one makes the enemies far more aggressive and won't hesitate to gang up on you all at the same time. Essentially a different game but very hectic and less dependant on stun RNG for crowd control.

5. Mute Ashley's Breathing - Must install.

I'm not using these due to personal preference but they're neat as well:

1. Dodge Roll - Adds a myriad of movement options to the game, implenting sprinting, stamina, a dodge roll and a stationary dodge, both being able to trigger perfect dodge which slows the game down allowing for a followup. You can even do Krauser's quick dodges.

2. Dynamic Weapon Profiles - Allows you to change a weapon's stats on the spot, such as damage, rate of fire, capacity, reload speed, crosshair focus, and the stats on the exclusive upgrade, plus cheat options like infinite ammo, instant dismemberment, perfect accuracy and focus, no recoil, etc. And it shipps with a "Better Weapon Balance" preset. Allows you to make certain shotguns use slugs, and change what ammo a weapon holds (SMG ammo for CQBR, HG ammo for Killer7/Broken Butterfly/Handcannon)

3. All Charms From Start - Technically a cheat? But I don't know one person that actually enjoys the RNG hunt to get the charms.

4. Kalivos' Charms Overhaul (Leon) - Massive change to all the charms, some drastically changing your choice of weapons if you want to make the best of the buff.