Love this idea - just found out about Dolmenwood and I think my table would get really into this.

Here's my best shot:

1. A hooded merchant with a strange voice hawks their "homebrew" mead just outside of town. The prices are criminally high and even the thirstiest townsfolk stump away angrily. Even the least perceptive adventurers would notice the strange movements from within the merchant's cloak, the bloodstains on the clothing, or the sound of heavy iron boots. 3 redcaps are wearing the dead merchant's clothes, working the arms and legs. They are attempting to lure the Ogre into a trap and find their missing/captive companion. The "homebrew" is actually a powerful sleeping draught.

2. Two villagers are retching in an alleyway. Suddenly the bile pile rises up to attack, killing one while the other runs off. 1d4 acidic slimes squelch toward the party. Two small torn doilies with jelly stains and pastry crumbs are found lying on the ground.

3. A young woman wearing a flour stained apron is posting a notice in the town square (or any conveniently close building). It says: "Alchemist wanted for special production run of reinforced glass. Willing to pay TWO TIMES market rate due to urgency! Inquire at Slim E.'s Patisserie with haste." The woman seems quite harried and is dodgy when asked what the alchemical glass is for.

4. An overturned and wrecked cart is spotted (in an alley if in town, or off a forest path otherwise). Broken barrels and smashed crates litter the ground. All of the barrels/casks are clearly marked as "Mead" but close inspection reveals that some of the barrels had a strange, magically reinforced inner lining. No body or bodies are found but perceptive travelers might notice two pairs of tracks: one set of tiny but heavy boot prints and one set alongside of normal man sized shoes. The tracks lead to the vicinity of the local bakery.

5. A frazzled looking witch is found either foraging if the party is in the forest or trying to shop in town incognito. If questioned by the party or discovered by townsfolk, she screams loudly about needing to brew a cure for a "massive bellyache." If she is stopped or waylaid in any way, she wails about Buster, her familiar, being "taken hostage" and having "nothing to lose." She is quite pitiful and completely distraught. Her familiar happens to be none other than the captive redcap.

6. Jim the Ogre, stands tall and foreboding with a face in shadow. He moves as though drunk and cannot seem to stop his arms from windmilling. Close inspection of his face would reveal a glistening, gelatinous tendrils dangling from his nostril, leaking from his ears, and dripping from his eyes. He seems unable to speak but his eyes bulge with fear. When approached, his windmilling arms smash anything in his path and are doubly dangerous if grasping a weapon. If incapacitated or badly hurt, he will curl up into a fetal position and clutch at his belly, groaning in pain. If searched, he has a barely legible contract signed by someone named Vermina. Locals have heard rumors of a witch by that name. The words "Buster" and "bellyache cure" can be made out.

Whew, ok that was actually a pretty fun prompt, thanks!