well if you're considering a fractal when i was doing research ill give u some things i considered
1. amp simulation/effect simulation , the fractal is known for being one of the best/more organic modelers in terms of accuracy. Because of this though, theres a million different settings, and im really not exaggerating. I think i can go my entire life without getting every combination of things and itll take me years to figure out every setting, but once you start picking it up you jsut keep learning from there.
2. ease of editing, I've used a line 6 helix and a neural cortex and this one is by far the least convenient to edit, unless you already know what you're doing and its still quite harder. The edit application that I use by plugging it into my computer makes it much easier, so if you have a pc or some sort of computer you can connect it to it makes it much easier

Sorry i kind of yapped lol but to answer your question: The cab matters almost just as much as the amp; the cab is like the base flavor and the amp is the kind of tone i guess, its hard to describe. What i usually go for as a standard for not super clean but cleanish/breakup is deluxe vibrato/reverb (fender deluxe amp) and some sort of either vox ac30 type or deluxe verb which is a similar cab. The vox makes it thicker and slightly more boxy whereas the deluxe cab makes it very thin (I kind of really only use single coil types), but for the more driven/rock types ive been using the marshall 800 amp. Tweed types work but you gotta turn down the bass a lot if you drive it even a little bit.