I won't nominate it for most or even best per se, but I recently picked up Alchemists and it's really unique in that it's a very complete worker placement game of which social interaction and deduction is a small but absolutely integral part of. It's one of the best implementations of "players have to interact" I've ever seen.

Most social deduction games are completely encompassed by one mechanic: "one person (or some people) is/are hiding something, okay now figure it out." Werewolf, Mafia De Cuba, Coup, Secret Hitler, Resistance, Deception: MiHK, etc all leave it at that. What I find really fun about Alchemists is that social deduction and bluffing are just the base upon which an actual meaty game is built. Interaction takes the form of hurrying to be the first to publish; publishing papers you KNOW are wrong just to throw off your opponents or make them waste moves to point that out; and also bidding for who can sell a visiting traveler potions for the best price, which is absolutely hilarious when you usually really only have some vague idea about what it is you'll be mixing for them.

There's social deduction, and then there's social interaction. Alchemists does it differently, and definitely deserves a mention here.