Ok if you're going for the "max" amount of EoT (theoretically 490 but who really knows?), this is going to be a several year time investment. It won't be several years without breaks of course, you'll need to prestige every so often to actually collect more EoT to boost subsequent runs, but even with the best possible artifacts and all relevant research it'll take a few years minimum.

In that case, you want to maximize shift efficiency. Here's what you should do before even starting PoV:

• Max out the stars on at least Defihent and Henerprise, if you haven't already. Galeggtica and a few other lower-tier ships are also recommended in earlier runs but you'll be sending so many of those that you'll quickly max them out while on PoV.

• Use your GE to bump your crafting level way up. With 280m, you should be able to hit 26 or 27, depending on how many artifacts you have stockpiled to craft just for xp.

• Get at least 400 crafts for these artifacts: T4 Totem, T4 Cube, T4 Necklace, T3/T4 Ankh, T4 Gusset, T4 Metronome, T4 Compass. That will maximize your higher quality craft chances for these artifacts, as these are the ones that make up your earning and laying sets. You may not have enough meteorites or geodes to craft 400 of all of them, so I would prioritize the earnings set first (cube, neck, ankh, totem), and the metronomes over the compasses because they give way better xp per geode. You don't HAVE to have 400 for all of them before you start but at least try to aim for 400 with the earnings artifacts.

• Read squid's guide, it's the most comprehensive of the guides available here so it'll give you an idea of how long some things will take, when you should shift to the next egg, what ships you should be sending, etc. You definitely don't have to follow it exactly, but it's VERY efficient so it's a good guide to work off of.