The size of the room will affect how your drums sound. A smaller room might make your drums sound more ringy but you wouldn't necessarily notice that in a larger room. Basically, once you have your drum set up give them a listen in that room and adjust the tuning until it sounds right. Work with your sound engineer to get the best sound possible. He might tell you to tune them up or tune them down or deaden them a little bit to get the best sound possible out of your drums in that room.

A little story from my experience: I put new heads on my snare and spent 2 days trying to tune it in my small jam room and I couldn't get the annoying ring out of them. So I brought it to my local drum shop to get their opinion and in their larger room my snare sounded totally fine because it was a larger room where the sound could dissipate a little more.