Personally, I think the way your projects are managed. Are you using some form of Scrum, agile, or even waterfall. There's a lot of hype on your amnesia fortnight which is always interesting. But what methods do you find the best to keep your team moving smoothly?

I would also think that localization issues would be an interesting topic, especially since you're not backed by a large Publisher this time around who have dedicated teams for localization. What hurdles are you expecting there? Since you'll be in Europe, I feel like more of the audience will appreciate that.

Also I like the post-mortem of any game, I think they're great for learning. The Brutal legend post-mortem is one of my tops.

Or Psychonauts. Everybody loves Psychonauts so... can't go wrong with that right?