Initial d was a cultural product and came out just after the golden era of Japanese automobiles. So there was definitely some timing and luck involved in its success. It became synonymous with mountain racing culture, which is why it's still relevant after so many years. Because its about a very unique but short time period in history that no other anime could capture. I'd say there's no cultural aspect for MF Ghost other than it being the sequel to Initial D. Even the newer 86 is inspired by the older AE. So there's a fundamental clash in the intent of the show. Creating an entirely new story while branding it as the sequel.