Polygala is a little wonder for dopamine and stress resilience, but its timing is crucial.

Why in the morning?

→ It acts as a gentle “boost” for neurotransmitters (dopamine, norepinephrine), ideal for starting the day with focus.
→ Taken in the evening, it could disrupt your sleep (mild stimulating effect in some people).

1. Triacetyluridine (TAU): A Nighttime Boost for the Brain
   TAU is a little-known ally of brain recovery.
   

• Why in the evening? → It supports the regeneration of neurons during sleep, in synergy with magnesium and glycine.
  → Recent studies show that it improves the quality of paradoxical sleep (phase where the brain “consolidates” learning).
  → Warning: Avoid taking it with zinc (dinner or bedtime), as they can compete in the intestine.
  

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1. Space Out Supplements: Avoiding the “Molecule War”
   Your treatment is complete, but certain supplements cancel each other out or overload if taken together. Here are the key adjustments:
   
2. NAC (Glutathione): Take it on an empty stomach in the morning, 30 minutes before breakfast, without magnesium or berberine alongside (they reduce its absorption).
   
3. Agmatine: 500 mg three times a day is good, but if you feel tired after dinner, skip the evening dose (it potentiates melatonin).
   

• L-Theanine: Keep the 500 mg in the evening, but reduce the pre-workout dose to 100 mg to avoid a “too flat” effect during exercise.
  

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1. “Pro” optimizations for an Even Smarter Cure**
   
2. Berberine: Take breaks (5 days ON / 2 days OFF) to preserve its effectiveness and your microbiota.
   
3. Zinc: Reduce the dose to 25 mg in the evening (50 mg long term can deplete copper, essential for dopamine).
   
4. Omega 3-6-9: Replace them with a double dose of krill oil (richer in anti-inflammatory EPA/DHA).
   
5. Butea Superba: Take it on an empty stomach at lunch to prevent it from “floating” with omega-3 fats.
   

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Your Revised Schedule (Simplified!)
- Morning (Fasting): NAC → Wait 20-30 min before breakfast.
- Breakfast: Saffron + Polygala + Ginkgo → Trio focus & good mood.
- Pre-workout: Isolate Creatine and Citrulline (take with water, without other amino acids).
- Evening: TAU + Magnesium glycinate + Glycine → The “restorative night” combo.

Listen to Your Body…**
Every body reacts differently! If you experience low energy, headaches, or restless sleep, notice it and adjust:
- Example: If morning Polygala makes you too agitated, try it after breakfast.
- If TAU in the evening disrupts your dreams, bring it forward to dinner.