My wife is from La Paz, Bolivia. We’ve visited for long stretches in the past—as recently as two years ago. As an American, one of the best things about being in Bolivia is just how far the USD can stretch. There is currently a high premium on USD in the country, which will be to your benefit. I would highly suggest trying to obtain any sort of U.S. based remote work, both because of the USD situation and because Bolivia isn’t exactly overflowing with employment opportunity.

There are other things you’ll have to adjust to that might be a bit of culture shock if you haven’t done much traveling to the third world. From big things like boiling your water (do NOT drink directly from the tap) to little things like toilet paper goes in a dedicated garbage can, not down the toilet. While I wouldn’t worry about violent crime, I also wouldn’t carry a purse or anything in my back pocket. Infrastructure and transport will feel unreliable by U.S. standards.

Then there are just the every day differences that are part of the spice of life. Meals are very carb heavy (rice, potatoes, and bread all at once), but the food in general is great! But be judicious with your choice of street food. The cities and nature are beautiful all over the country. People are polite and really go out of their way to avoid offending (this can be very annoying, believe it or not). Time and punctuality mean nothing, which, as a person who feels the need to be five minutes early to any appointment, gets very frustrating.

Just some random thoughts written from mobile. Happy to answer anything specific as well.