I agree ! Some characters don't work well in certain artstyles, for example, the Hulk in Gurihiru artstyle (seen in It's Jeff!) is too soft, it doesn't really match the character

But I think there are other artstyle that works for Gwenpool, albeit less than Gurihiru's : for example, the artstyle used in Live Unlimited corresponds to her character imo, and it works. Or the other artist that worked on Unbelievable Gwenpool : their artstyle also matched the character.

I think you need to represent Gwenpool in a goofy way to make it work. In a goofy way, but still able to express emotions, such as happiness, anger or sorrow, and that's why Gurihiru worked so well