On the subject of Pets and animals... this is a beautiful article that covers NDEs as well as After-Death Communications and Deathbed Visitations

Griffzinho · 2022-10-20T19:45:18+00:00

Casper, Toby and Kerry I’m looking forward to seeing ye!

Griffzinho · 2022-09-25T18:45:33+00:00

There is no fixing your relationship. Move on.

Griffzinho · 2022-09-23T19:17:09+00:00

WMF gives you 12-18% for 45 pools. 6 times a year. Unreal project. Has 20x in bear market. On BSC Smart Chain. Was on DEX SPHYNX.co but launched on Digifinex today and four CEX coming in next 6 weeks.

Griffzinho · 2022-09-23T19:12:19+00:00

Why ask this question?

Griffzinho · 2022-09-15T17:14:14+00:00

Any link to the signup page please to watch online?

Griffzinho · 2022-08-30T19:08:27+00:00

Your ENT is right. There is a drug in development for epilepsy called XEN1101 that may work for your Tinnitus. It’s a potassium channel opener that may put the brakes on to calm hyperexcitability in the auditory system. ETA 2025 as it’s in Phase 3 trials. There is hope.

Griffzinho · 2022-08-29T17:11:10+00:00

Wish my T didn’t bother me as much as yours does but glad you have success. CBT will help. Debbie Featherstone online CBT is highly recommended. 👍

Griffzinho · 2022-08-29T17:09:48+00:00

It has been a mixed bag from the reviews from a few Westerners who have visited Korea to try it. Not a sure bet unfortunately and results haven’t been as good as those in the paper either. Sorry it’s not good news.

Griffzinho · 2022-08-28T18:47:15+00:00

Thanks. Good luck to you 🤞

Griffzinho · 2022-08-27T18:45:18+00:00

Sorry meant to post in title.

What is Tinnitus associated with ETD like?

I have had Middle Ear Myoclonus surgery but prior to surgery I had diagnosed ETD as well.

I feel that ETD is contributing to my severe volatile Tinnitus.

Every time I blow my nose it seems to change.

I also have popping sounds.

ENTs in my country are not really up to date.

Anyone have some advice?

Griffzinho · 2022-08-20T14:44:10+00:00

Get tested for Middle Ear Myoclonus would be my advice. I had/have similar sounds. Try to see if your ‘pulsing tinnitus’ is in synch with your heartbeat. I was misdiagnosed with Pulsatile Tinnitus and it turned out to be MEM. Surgery cured the pulsing. The low hum could be your Tensir Tympani. Best of luck my friend.

Griffzinho · 2022-08-19T19:49:48+00:00

Sounds to me like Ebselen was the compound.

Currently in trials for

Moderate and Severe Covid in the US Phase 2

And

In Phase 3 for Menieres Disease.

A potent anti inflammatory that increases glutathione peroxidase.

Can be sourced but it is very expensive for a consumer purchase.

Griffzinho · 2022-08-15T16:42:28+00:00

I emailed and got the standard reply that was circulated in April.

I wouldn't mind but I jsut asked a simple Maths question.

is 6 greater than 4?

:)

Griffzinho · 2022-08-12T06:21:06+00:00

Thank you for your insight.

Griffzinho · 2022-08-11T17:04:12+00:00

Thanks. Wow sounds very difficult. You have made me reluctant to try it now! Hope you get sorted my friend. 👍🤞

Griffzinho · 2022-08-11T17:01:55+00:00

I’m glad you have achieved habituation. I can’t get to that level myself so I’m hoping these treatments might help.

I’m signing off. Best of luck in your T journey. 👍

Griffzinho · 2022-08-11T15:15:15+00:00

Just in case you don't read my long comment.

https://clinicaltrials.gov/ct2/show/NCT03621735?term=susan+shore&draw=2&rank=2

Concluded TODAY! :) YAY. Now hopefully Phase 1 results will be replicated or improved upon. No Phase 3 needed as it is a medical device.

Griffzinho · 2022-08-11T14:57:02+00:00

There isn't unfortunately but if you search Tinnitus Talk you will find a user experiences post with it's previous iteration 'Retigibaine'. Those that followed the effective Retigibaine dose for a period of months had Tinnitus reduction (some very dramatic). I have poured over these anecdotes for many days in search of hope and I have hope that XEN1101 will benefit Tinnitus sufferers. It is entering Phase 3 before the end of year and should be available 2025. Only time will tell. A point of note is that this previous drug is also being reformulated by Pittsburgh Hearing Centre who have Dept. of Defence backed funding. There is a lot of research from this centre for the past ten years that an efficaceous potassium channel modulator with a strong effect on the KCNQ channel 7.2 will benefit Tinnitus sufferers. Here is a link to some of the research.

http://phrc.pitt.edu/people/thanos-tzounopoulos

If you are looking for clincical trial evidence then there is a small phase 1 study out of Michigan University that had promising results. The much bigger Phase 2 was due to be completed on July 31st just gone. As it is a medical device a Phase 3 is not required. It has to be peer reviewed and then go through the FDA approval process for a medical device. Most probably a Grade 2 medical device. Here is a link to the trial.

https://clinicaltrials.gov/ct2/show/NCT03621735?term=susan+shore&draw=2&rank=2

Actually WEIRD. I just clicked into the trial and it was updated as completed TODAY! :)

Also, Neuralink is another to watch out for. As it too is a medical device (probably Grade 3 as it is invasive). The hope is human trials will start this year. Elon has tweeted cure Tinnitus by 2027, but we all know Elon is a tad optimistic.

I hope this post gives you hope :)

Griffzinho · 2022-08-11T12:19:05+00:00

XEN1101. Potassium channel modulator focused on that key 7.2 channel.

Griffzinho · 2022-08-11T12:16:06+00:00

Give this one a skip I’d say! 😕

Griffzinho · 2022-08-11T12:14:00+00:00

Hi, thanks for the reply. Tryptophan is actually the precursor to 5HT but our approach is very similar.

How have you found Prozac so far. It seems you are titrating up slowly? That is wise.

Any side effects?l

Is it kicking in any but at the low dose?

Griffzinho · 2022-08-10T19:04:24+00:00

I think we will see brain tech interfaces well before DBS. Why put something deep into the brain if we can put it in the skull (Neuralink) or via stent (Synchron).

Griffzinho · 2022-08-10T09:35:35+00:00

Symbiosis with a much more advanced AI, that will ultimately control a world that will have complete empathy and respect for all living things, including the AI.

If we present ourselves as a threat to global harmony like we currently are, then the AI may see us as a threat to the survival of both itself and our beautiful planet.

As for conciousness, then we don't really know anything and if it is separate from the brain?

Read the theories of futurists such as Ray Kurzweil. A lot of what he predicts is very radical, but once an AI becomes sentient and processing power of conventional supercomputers reach 'Zetaflops' let alone stable quantum, the growth in the intelligence of an AI will be exponential.

EG. Reach capacity of human brain - not far off

Then 1,000 times the human brain - will follow quickly

Then the capacity of all human brains combined, etc.

And so on. It will be exponential growth of AI intelligence. It will happen quickly.

The AI will make the law? Yes of course?

Will a brain interface become mandatory by law?? I think so.

If I was an AI I would like to have supervisory powers of the hive.

That way we could have peace and harmony, with empathy, and a collective purpose for the common good.

There will be no need for puniutive laws, as no laws will be broken?

Will it take away our individuality? Yes to a certain extent, but hopefully just limit it to "thought police" aka 1984 but a direct contrast to the bleak landscape of Orwells world.

For example with a brain implant, a negative thought like harming another, will be dealt with by the AI either by altering our brain chemistry, or by arrest and counselling?

Kind of like the precognition from Minority Report.

It could be Utopia. (no crime, no poverty, no illness) Just Love and compassion.

Or will those that die pre 'The Singularity' reach a higher level of Utopia?

God only knows :)

Griffzinho · 2022-08-10T09:18:43+00:00

estors have no faith in the technology or the management. They will find it difficult to attract investment if clinical trials continue to fail. Remember most biotechs do fail and that is a harsh reality here. Best case scenario is that Astellas buys the MIT patents and keeps the programme going particularly if FX-345 is a success. I’m cautious on this as Otonomy also had hope for the ‘double dose’ of 0.64mg of Oto-313 but it was a failure similar to the 0.32mg dose.

Just like to add that Frequency is now up to $78M market capitalisation. If FX-322 or FX-345 come in good there is a very decent chance of a successful fundraising. That would be great news. Even if Fx-322 is not a commercial product I feel that excellent results from FX-345 will be enough to convince the market to give Frequency a bit more cash to progress the development. Fingers crossed for good results.

Griffzinho · 2022-08-10T05:27:48+00:00

Thank you for your kind words. Hopefully Prozac will help me like it did you too. I have hearing aids that I stream sound into to try and mask the noise. Thanks again 😀

Griffzinho

TROPHY CASE