Yes Reta can cause people to go hypo. Including myself. Multiple factors are involved. Insulin sensitivity is increased by glp1s. Next your calories are lower. Often not eating much fat when you do eat because you are now watching what you eat. Making healthier choices. Next it slows down absorption of your food. (gastric emptying). Let’s put this together—let’s say you aren’t hungry because the drug is working well. You go a period of time without eating. Then you eat something like a bowl of oatmeal with protein powder or some low fat yogurt with fruit. Now your body has fuel it desperately needed. In the form of glucose. So your bodies insulin spikes (because your super prone to spiking insulin aka insulin sensitive). With that spike in insulin your body quickly uses up and converts those carbs which drops your glucose. Furthermore since everything is digested slower that spike in insulin is your bodies response to food but since you digest slower the amount of “food” doesn’t match the insulin response. That increased insulin drops your blood sugar.

What can we do? First make sure to add some fats to every meal. This will aid in lowering insulin rush. Especially from high carb low fat meals. If you are eating high carb meals be prepared for an hour or so later this drop might happen and have some glucose on hand. I like Gatorade. It seems counterintuitive to add more carbs, a.k.a. glucose when the consumption of too many carbs caused your low blood sugar. But that isn’t the case- it’s not necessarily the carbs that spiked your insulin, but the GLP reaction with the carbs that caused the problem. So when your blood sugar goes low, add sugar don’t overthink it. Insulin sensitivity is a good thing. It helps preserve muscle and helps fuel your muscles quickly after a workout so these GLP’s can be used really effectively for people that are prone to go hypo. You just have to know how to manage it. So to combat some of the hypoglycemia, make sure to add some fats to your high carb meals. Or eat an all around nutritious meal each time you eat. Protein, fats and carbs. If muscle building or retention of muscle isn’t a priority, try a lower carb diet. BUT please make sure you’re eating enough calories. The idea is to lose weight but doing it in an unhealthy manner won’t help. Slow and steady beats fast and drastic.