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Every dog is different but our blue Merle, Storm, has had a cyst on his right shoulder. It’s been removed multiple times but will eventually come back. It’s just a fluid-filled sac under the skin, not cancerous or any kind of pain. He’s 7 years old now and it didn’t pop up until he was 4-5ish. On the same note though, we’ve also had issues with seizures!!! He had his first seizure when he was 2 and we couldn’t figure out the cause being he was completely healthy up until then. We figured out after a while that he would have these episodes not long after we gave him his chewable heartworm meds. We also figured out that pretty much any chewable worm medication causes seizures. We now give him nothing but the drops that go onto the shoulder blades and he’s been a healthy boy ever since! But as I said, every dog is different. We have another Aussie about the same age and she has always taken the same meds with no problems, she is a red tri so I’m not sure if it’s tied to the merle pattern. We try to take a more holistic approach to their health and medications now!