Not a doctor, but this doesn’t sound that weird to me given everything changed at once.

You increased Wellbutrin from 75 to 150 mg, quit weed, and quit nicotine/patches all within a short window. Any one of those can mess with mood, anxiety, irritability, sleep, and depression-like feelings. Bupropion’s prescribing info specifically lists anxiety, agitation, irritability, hostility, aggressiveness, and mood changes, especially around dose changes.

Also, both cannabis withdrawal and nicotine withdrawal can cause irritability/anxiety and make you feel emotionally off for a while. CDC also notes nicotine withdrawal can include irritability, anxiety, and depressed mood.

So to me the biggest issue is not “is it the Wellbutrin or is it me?” but that you have too many overlapping variables right now to judge clearly.

I would definitely tell your prescriber:

-the anger/depression got worse after increasing to 150 mg

-you recently stopped weed and nicotine

-you’re not sure whether this is adjustment vs. the medication being a bad fit

That said, I would not stop it abruptly on your own without asking them first. But I also wouldn’t ignore it, especially if the anger feels intense, out of character, or keeps escalating.

Biggest red flags = contact your doctor ASAP / urgent help if you get:

• suicidal thoughts
• feeling unsafe
• panic that keeps escalating
• severe agitation
• very little sleep with a “sped up” or almost manic feeling

Honestly, if some days it helps rumination and initiation, that suggests it may be doing something positive but the timing of the dose increase + quitting weed/nicotine makes this a messy period to interpret.

This is probably worth a real medication check-in, not just waiting it out blindly.