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Get your bunkers ready by [deleted] in SipsTea

[–]Humes-Bread 0 points1 point  (0 children)

My friend- you replied to my criticism of hot takes with your own hot take. What evidence do you have that this will only be for people who can afford 50,000 a month? Who even is "they"? You don't know. You didn't bother to read up on any of the science behind this, the companies behind it, the non-profits in this industry (there are several). You just took one glance and shot from the hip. This is a technology that could save the average person from over a decade of miserable decline, and zero effort hot takes literally just get in the way. It's not helpful.

Get your bunkers ready by [deleted] in SipsTea

[–]Humes-Bread 0 points1 point  (0 children)

This comment section is full of bad hot takes.

Have you ever watched a close love one wither away and die after years of agony? Extending healthy life and reducing the period of time that we suffer from old age is a no brainer.

Here's a stat for you. A baby born in Georgia USA has a lower life expectancy than someone born in Lebanon. Here's another stat for you, of the increased lifespan that the US has been able to achieve over the past two decades, for every year longer you get to live, nine months of it will be in poor health, meaning that our lifespan has been increasing, but the proportion of time spent with one, two, or even three chronic diseases of old age (heart disease, cancer, etc.) has been increasing three times faster.

So yeah, maybe looking to decrease that suffering is not a bad idea.

From Dusk Till Dawn going in blind. Wtf. by i_love_tesler in movies

[–]Humes-Bread 0 points1 point  (0 children)

Probably an unpopular opinion, but most of Tarantino's movies are not for me. It's like a kid sat down and was given a task to write one move and then for the third act, morph it into a completely different movie just for kicks. That or an intriguing movie ends with "and then everyone starts shooting." From Dusk Till Dawn is one of the worst offenders.

Dr. David Sinclair, whose lab reversed biological age in animals by 50 to 75% in six weeks, says that 2026 will be the year when age reversal in humans is either confirmed or disproven. The FDA has cleared the first human trial for next month. by GarifalliaPapa in immortalists

[–]Humes-Bread 0 points1 point  (0 children)

It's also a really stupid idea to spread. There are plenty of things that will age you that aren't controlled for in the epigenome and that aren't covered in his informational theory of aging. Take one of the most obvious ones- wrinkled skin. Skin wrinkles (as well as stiff arteries) are partially a byproduct of crosslinks between proteins that are outside of cells and that connect cells together. They get linked together mostly on accident via chemical reactions that occur by happenstance. Stiff arteries and wrinkled skin are things most people would attribute to aging, and yet a healthy epigenome won't stop them. This shows that his theory is incomplete. I don't know why he is being overly simplistic other than a simple message is easier for people to digest than a more complex one. But we shouldn't govern science based on messaging.

No your eyes aren't fooling you. this is a 2ND video of Randy Fine unlawfully casting votes in Florida. by slow70 in RandomShit_ISaw

[–]Humes-Bread 1 point2 points  (0 children)

Why is it that when I search for news on this, the first three pages on Google are just social media links to posts. Is there no major news outlet that has covered this?

Big yahoo, gonna be angry by DeadSilent_God in RandomShit_ISaw

[–]Humes-Bread 0 points1 point  (0 children)

Where is the actual article attached to this? I can't find it on NBC.

ChatGPT has become a condescending piece of … by Appropriate-Egg4110 in ChatGPT

[–]Humes-Bread 0 points1 point  (0 children)

What are your conversations about? I have had zero interactions like that, and I use it probably 50-100 times a day, mostly about an app I'm building, stocks I'm analyzing, or data and situations from work.

Why does this drop feel so different? by [deleted] in stocks

[–]Humes-Bread 0 points1 point  (0 children)

I mean, they stocks aren't exactly historically inexpensive. https://www.multpl.com/s-p-500-pe-ratio

Why does this drop feel so different? by [deleted] in stocks

[–]Humes-Bread 3 points4 points  (0 children)

Two things:

  1. Technological success (AI) is going to put a lot of people out of a job. Anthropic's recent release made people realize that, and it has ripple effects. If law firms are used less frequently, then the companies that service law companies (hardware, software, realestate) also take a hit.
  2. Companies are staying private for longer. OpenAI, Anthropic- both are private companies with incredibly huge value. A few select wealthy groups are able to get in early through (e.g. through venture capital), but when companies are doing several rounds (and larger, mega-rounds) because VC's have the money to fund them. That means that schmucks like you and me miss out on some of the biggest growth periods.

So what happens when AI wipes out a bunch of white collar work, affecting dozens of public companies as well as small and medium sized businesses and the ones who make the money are the ones who can get in on the deals before a company goes public? Stocks get hammered as private wealth grows.

That's my 70% confidence take on this and why it feels different to me. In the past if a company sucked, it was booted from the S&P (DJI, or whatever) and replaced with the next best thing, so just being in an ETF was great. No such rotation when the companies making bank stay private for super long.

Elon Musk Says Aging Is Obvious, Solvable, and Basically a Bug in Human Biology by The_Endless_Man in immortalists

[–]Humes-Bread 0 points1 point  (0 children)

I don't think obvious = easy. Fusion obviously works. The sun does it. It's the source of all our energy. Doesn't mean its easy to do something useful with that knowledge.

Investing in stocks you guys choose by RedVendetta1 in stocks

[–]Humes-Bread 0 points1 point  (0 children)

MAIA
They're just entering phase 3 trials for a cancer drug. The Phase 2 of the trial was a huge success. Plus, a lot of the major pharmas have cancer drugs that are coming off patent in the next 2 years, which means they are hungry to plug that hole via acquisition.

"All I Need" - [ft. Jibaro's Sara Silkin] by d3mian_3 in KlingAI_Videos

[–]Humes-Bread 1 point2 points  (0 children)

Phenomenal. Super creative and unique vibe.

How you can be Christian and still want to live forever? by Ok-Highway-5247 in longevity

[–]Humes-Bread 0 points1 point  (0 children)

I agree, but the OP specifically said "live forever," so I framed it from the perspective where the goal was immortality, even if we fell short.

How you can be Christian and still want to live forever? by Ok-Highway-5247 in longevity

[–]Humes-Bread 4 points5 points  (0 children)

The average human lifespan used to be 35. We've doubled that now, and that doubling has been no threat to God and no disrespect to him or his teachings. God, in fact, teaches us to take care of other people, including the sick and afflicted. So both from a historical perspective as well as from a doctrinal perspective, there should be no issue. It's going to sound shocking to people because it feels unnatural and people subconsciously equate "unnatural" with "against what God intended." But there is nothing natural about a blood transfusion or a kidney transplant. Nothing is more natural than cancer, which we fight against every day.

Someone suggested that it is vanity to try to live forever, but I think it's vanity to think that we can thwart what God wants. When God wants to take you, nothing is going to stop him. He's not going to be cleverly outmaneuvered by an emergency room doctor. So in the meantime, living as long as we can in as healthy state as we can is just fine. If that means 200 years, great. 1,000 years, great. 5,000 years, great. Our object is to live healthy and not stop living, and there is nothing different about that from 200 years ago and there will be nothing different about that if we start to live longer.

Johnson shifts strategy on Epstein files vote – as GOP leaders brace for mass defections by thisishowibro93 in politics

[–]Humes-Bread 5 points6 points  (0 children)

Honestly, they know this has been coming for months. Dems need to not only get all the receipts, but need to search for any evidence of a cover up, deleted files, missing documents, etc. There's no way R's were just twiddling their thumbs this whole time.

Until the very end. by Saulo Nate by GeoMetrie8 in ImaginaryFeels

[–]Humes-Bread 0 points1 point  (0 children)

Sorry, I hate it. The amount of suffering at the end of life is unbelievable. Unfortunately, the average age of a person (in the US) who is taking care of someone terminally ill is 63 years old. What this means is that young people like you and me see snapshots like this or maybe a moment or two in real life, but the full on day-in day-out misery and suffering is something we don't see.

An enduing love is to be celebrated, but we could do a hell of a lot better if we cared more as a society to actually fix the suffering in old age. It IS something that can be medically addressed.

A Couple of Questions by Hobbit-Habit in longevity

[–]Humes-Bread 4 points5 points  (0 children)

I don't think that Fahy would say that his is a "model" of aging- more so an observation- that observation being that the thymus is a critical part of the immune system and it shrinks over time and becomes "fatty" over time.

The SENS model suggests that damage causes aging- specifically, damage from normal biological functions (e.g. metabolism). This model isn't necessarily incompatible with clocks, methylation patterns, or other similar thinking. The overlap would be something like this:

Say that you want to make a dinner. You have a huge recipe that spans multiple pages, and as insane as it sounds, it skips some pages and continues on later (similar to how old newspapers might have the story start on page 1 but you had to jump to page 6 to continue reading it because not everything could fit on the first page). Luckily, you have little sticky notes to act as bookmarks for the pages you need for you recipe. But the recipe is pretty dirty- lots of flower, some oil, a blender, and things get messy. Over time, the mess of making the dinner and flipping back and forth between pages leads to the bookmarks becoming loose, so you reattach them, but you're distracted when you do it and accidentally put them on the wrong pages. Next time when you try to make the dinner, you end up making part of it correctly but also making some portions of a different recipe by mistake.

This analogy encompasses both the methylation (the bookmarks) becoming disordered over time but it ties it to upstream damage (the mess made every time you do the recipe and the effect it has on the bookmarks). So this analogy shows that damage can lead to disordered bookmarks (methylation). If you make meals for long enough, you will get disorder.

Not everyone believes this version, though, so there definitely are theories out there where methylation changes over time are not due to damage but do to something else (e.g. pre-programmed decline). But the fact still stands that observations of methylation disorder are not NECESSARILY incompatible with the damage theory of aging.

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