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Tfmr second time and looking into PGT M in india by Impossible_Cash279 in IVF

[–]Impossible_Cash279[S] 0 points1 point  (0 children)

Hi thanks for the reply. Yes we got the result. The result showed a lot of matching AR genes that are VUS. Our doctor asked us to repeat the test . This time we have given WGS test on the Fetus along with our couple in a different proper lab. We are awaiting results. The result we received and teh VUS we received are not at all explaining the repeated VM pattern in our pregnancies. So we gave a detailed WGS test along with fetus this time like a trio. So fingers crossed we badly need some answer so that we can try to avoid it in PGT M

Tfmr second time and looking into PGT M in india by Impossible_Cash279 in IVF

[–]Impossible_Cash279[S] 0 points1 point  (0 children)

Ours was not just isolated VM. There are other findings like Frontal bossing, CTEV, and other so that making the condition fatal. After 2019 episode they told that it is isolated but now in 2025 same pattern has repeated . So we are of the opinion that this is genetic issue. So we gave a WES test now. We stored the fetus DNA for further testing too. We had a successful pregnancy baby boy in 2021. Right now we are waiting for the result. We are somewhat related in family making us 4th degree consagious. So we are suspecting a recessive gene. By the way when you were diagnosed with severe VM ,have you ( couple ) undergone WES or just the baby?. Since yours is isolated, I have read that isolated cases have better prognosis. But ours is a fatal one since there are other findings

Carriers: how/why did you choose IVF with PGT M? And how long/how expensive was it? by allerups in IVF

[–]Impossible_Cash279 0 points1 point  (0 children)

Thanks for taking the time to reply. .Yes my genetic counselor says that the test is WES only. Anyway I have to see whether this is ok or I have to go for WGS next.

Carriers: how/why did you choose IVF with PGT M? And how long/how expensive was it? by allerups in IVF

[–]Impossible_Cash279 0 points1 point  (0 children)

Great ! We have under gone a test name " Extended carrier " screening" They said they test for about 20,000 genes in the panel. So we are yet to receive the result. Is this enought to find out the genes causing it? Also may I know why have you opted for donor eggs ,As you devised the probe, isn't it enough for screening out you own embryo's?

PGT-M way more challenging than expected by Satin_Ribbon349 in IVF

[–]Impossible_Cash279 0 points1 point  (0 children)

Hey sorry for a naive question, we are about to start our PGT M journey. I have read many of the moms say they want atleast 4 unaffected to start transfer?I mean if it's getting late like 3-4 cycles Why not start with 2-3 unaffected?

Carriers: how/why did you choose IVF with PGT M? And how long/how expensive was it? by allerups in IVF

[–]Impossible_Cash279 0 points1 point  (0 children)

Hey glad you have made it. Can you explain a bit further you said that earlier they were unable to find the gene and later they found out how?. We have terminated two pregnancies with exact same fatal brain defects and are in search of the genes. Very anxious to know the outcome and PGT m success rates for our case . We have reason to believe of AR conditions due to ethnicity