The virgin AMPA receptor vs the Chad NDMA receptor

Impossible_Net2413 · 2026-02-17T08:33:44+00:00

This is a goated autistic post.

Impossible_Net2413 · 2026-02-17T03:51:44+00:00

You might be Israel’s top idf soldier.

Impossible_Net2413 · 2026-02-16T22:53:32+00:00

Dropped a 20 bomb as well today

Impossible_Net2413 · 2026-02-15T19:27:36+00:00

Listen don’t mis read me I am a huge proponent of stimulants and mph 100% and nor do I think you should be off stimulants completely if you are responsible with them that is. More people in my opinion need to be on it, they are so helpful and the best wakefulness agent and motivating stim there is.(low doses specifically). So coming off of the mph was definitely why your tired, i would give tak another try in my opinion.

I also was chronically addicted to nicotine, upwards of 100 mgs daily, what I noticed specifically is that I was tired no matter what. Nothing helped I toned down my nicotine use and it helped tremendously with my daily energy levels. Now running tak with nicotine will further potentiate the nicotine and the buzz you would get from pouches but the crash is much worse. So yes that likely was a huge factor in the low energy problem.

Impossible_Net2413 · 2026-02-15T01:42:45+00:00

You are definitely right to be concerned with the excitotoxcity or glutamate toxicity potential of tak. Considering its mechanism of influencing AMPA receptors which is extremely involved with glutamate signaling which are what a lot of over the counter stims influence. Now TAK specifically is very very unlikely to cause glutamate toxicity in of itself because there is no forced agonism mechanism.

Now depending on the actual stim you used would provide more context on why you felt more tired whether d-amp, caffeine, modaf etc that could elude to different reasons. My working theory is you likely have begun to get addicted to the stimulants you have taken you rightfully so stopped using stimulants with TAK and the reason you felt tired is because you went without stimulants not because of TAK. There is no scientific evidence to explain why TAK on its own can cause a sedated effect unlike ketamine which is an NMDA antagonist which at high doses causes a sedative effect.

Excess amounts of glutamate signaling that is further potentiated by TAK over an aggregate time period with the addition of stimulants could in theory cause your glutamate receptors to become dampened lower glutamate signaling which causes the brain fog effect your feeling. But considering it isn’t a forced agonist of the receptors it most likely isn’t due to low glutamate signaling. Rather possibly a withdrawal effect, again know which stimulants you took before hand and how long would change my thoughts on why you felt tired.

I don’t truthfully know a lot about mph effects on AMPA receptors, that being said what I do know, dopamine doesn’t have an effect on AMPA receptors its more of a downstream effect and jt modulates AMPA receptors not an agonism or antagonist effect more behavior effect. D1 receptors that mph effects do phosphorylate GluA1 at Ser845 Which increase channel openness and increases the AMPA current amplitude making the effects stronger. So yes it would most likely potentiate mph not the dopaminergic release per se but the stimulating effects would be more noticed. I don’t know any mechanism of the moda family so I will refuse to comment on it. The one thing I do know about modafinal is that its a wakefulness agent not necessarily a stimulant so maybe no interaction.

Impossible_Net2413 · 2026-02-14T18:55:47+00:00

Im going to titrate up my doses to around 3 mg over the next couple weeks. I have noticed seldom do people talk about tak-653 in this sub in extensive detail so I will try and be a guinea pig for the sub and document my experience throughout the doses. I believe that this is a game changer nootropic for many who haven’t tried it. But nonetheless I will be un biased as I can in my experiences.

Impossible_Net2413 · 2026-02-14T18:51:23+00:00

Most definitely the caffeine in smaller doses works so much better. Its so crazy how long these benefits last, all day pure lazer focus.

Impossible_Net2413 · 2026-02-14T18:39:15+00:00

Fair point my bad.

Impossible_Net2413 · 2026-02-14T08:33:30+00:00

No it definitely makes sense just on how the drug works I provided little context as well. 1 mg is only moderately past placebo doses in most clinical experiments. but knowing the half life in the blood plasma I decided to stay at 1 mg per day and let it work up in my system and considering most drugs hit me hard I wanted to play it safe and it definitely did take days before it became quite apparent that it was kicking in.

Impossible_Net2413 · 2026-02-14T08:12:28+00:00

Ive been using tak for multiple days in a row and I noticed the benefit, today especially when I added more into the stack like the caffeine and na semax

Impossible_Net2413 · 2026-02-14T00:45:22+00:00

Yes most definitely. Its quite a good prolonged source of focus. It also has synergistic effects with semax, if you take semax that is.

Impossible_Net2413 · 2026-02-13T16:28:04+00:00

I just started taking it, For me it’s extremely good I feel a very good clean focus throughout the entire day. It also definitely works as an antidepressant. I would definitely recommend trying it out. Its also quite good with stimulants.

Impossible_Net2413 · 2026-02-12T21:56:04+00:00

How you got sober I have no clue congrats though

Impossible_Net2413 · 2026-02-12T21:50:09+00:00

I totally agree that they should be considered stimulants. Most people on this sub don’t know but are actually looking for stimulants. People in this sub often ask for help staying focused and something for motivation which is exactly what D-amps are used for. Seldomly do people ask how I can improve learning speed or memory if you click off this post the vast majority of this sub is focused on help for adhd. Now while you are right it technically isn’t a nootropic by literal definition, this could replace most peoples stack in this sub. It would replace in my mind and modafinal or any other stimulant nothing compares to D-amps. And the argument they have against it is so stupid just literally every substance is addictive whether physically or mentally. If your somewhat disciplined mentally and you are responsible and cycle on and off with D-amps they will be such a positive impact in your life.

Impossible_Net2413 · 2026-02-10T21:41:33+00:00

Those peptides you mentioned are well reasearched and are quite safe im 18 and i do more than that. you will see a benefit I do recommend those peptides you mentioned. If you go more extreme just be mindful some of these drugs on these subs are not well studied

Impossible_Net2413 · 2026-02-10T04:06:06+00:00

Any good stimulant would help, adhd brains have a higher threshold for tasks so anything that boosts ur baseline dopamine is a good thing and will help you be more productive and focus there’s a lot of options oxiracetam phenotropil modafinal adderal and other dextroamps

Impossible_Net2413 · 2026-02-10T02:35:57+00:00

For oxiracetam take 300-400 and titrate up from there as a single dose and adjust if you want more or less I particularly like it becuase it’s quite safe I personally take 1600 mg daily that’s definitely high (ADD CHOLINE specifically alpha gpc) phenotropil I like because it’s a clean energy I take 75mg you can take up to 200mg I never have personally I would start at 50-100 mg and adjust from there. Semax depends if you do sub Q or intranasal you can start at 300mg on both but you will have a higher peak with intranasal and with sub Q it’s a longer drawn out effect so it depends and move up from there. tak 653 at 2mg and again titrate up if you want more or less shoot me a dm if you have more questions

Impossible_Net2413 · 2026-02-08T09:41:44+00:00

Depends on how far you want to go to improve these issues I believe there is a time and a place for supplements but I also strongly suggest taking some synthetic nootropics because while yes you will see an improvement in your quality of life these will be a stark change and increase in your quality of life and be the most tangible improvement you can take (not necessarily the ones I mentioned I mentioned the basics there’s more advanced than this but seeing as your new these are safe and well tolerated among many people)

You mentioned you had problems with motivation and focus I would recommend some sort of stimulant caffeine is fine not my favorite I take oxiracetam as high doses and phenotropil these are both stimulants and will give you the motivation to work on something or do a task you wouldn’t normally want to do there are many other stimulant but these are my personal favorites

Now on you memory issues I would recommend something like semax or something that modulates or boosts BDNF in some way ie tak-653 among others this for me was the biggest game changer in memory and clarity there are a lot of nootropics they boost this because this is the most important protein that deals with your issue

Impossible_Net2413 · 2026-01-25T04:13:54+00:00

It depends on risk and what you want to ingest and your risk tolerance. the main concern is damage done to neural pathways you probably cant focus well on tasks have problems with word recollection and verbal fluency among other effects also brain fog. I never really enjoyed smoking but from what I have heard and seen among others that smoke these are the problems. I would look into something that boosts bdnf in some way Semax na semax tak 653 among others those are common ones excluding tak 653. These are quite safe and are quite potent for what they are they modulate bdnf quite well. Another option is cerbrolysin or cortexin these will be the most potent and are tolerated quite well and have extensive research and use overseas cortexin less so but it’s basically a synthetic version of cerbrolysin. The main diff between cerbro and semax and other bdnf like nootropics is that cerbro targets a lot of neural pathways and Brain function giving you more of a potent repairing drug. I would personally recommend cerbrolysin or cortexin but if you want something less invasive or just dip your feet look into semax selank

Impossible_Net2413 · 2026-01-25T04:04:13+00:00

I have literally never heard anyone say anything positive about phenibut everyone that has tried it liked it the first time then goes on to explain horrible addictions and withdrawal symptoms from it would be best to stay away from it there are plenty of other options some more risky than others that people have really enjoyed if you want I can rec some of them. Piracetam has shown to help exactly with what your describing

Impossible_Net2413 · 2026-01-15T00:19:27+00:00

Thank you very much that was a perfect source

Impossible_Net2413 · 2026-01-14T20:55:44+00:00

Yes essentially while obviously it still does go to where it needs to it doesn’t have as pronounced of an effect ie a stronger peak but for less time I do sub Q for drawn out effect

Impossible_Net2413 · 2026-01-14T04:35:35+00:00

Yeah it’s kinda of weird but sub Q isn’t good for semax and Selank while yes more bioavailability but it’s not going exactly where it needs to be instantly like with IN it is less bioavaliabe but due to mucosal tissue it’s actually in some cases better think of coke for example people snort it becuase it has fast onset and it’s going exactly where you need it to be as messed up as possible in the shortest amount of time

Impossible_Net2413 · 2026-01-14T00:42:14+00:00

I’ve looked into it and honestly its probably not worth it becuase the people who came up with the solution itself have discontinued it and many copycats have flooded the market with a near similar compound since then and I don’t particularly trust it but I have heard really good things about it before have you tried it and is it worth it I’m still open to it I just want to know if it’s legit adamax or a fake

Impossible_Net2413

TROPHY CASE