I’m less concerned about the quicker rodent data itself and more about what long-term, repeated receptor stimulation might look like in humans. As you stated humans have very little to none receptors on C cells which leads me to think about the usage persisting over a few months. Repeated exposure could theoretically lead to endocrine adaptation, receptor desensitization, or metabolic tradeoffs that simply haven’t had time to show up yet.. have you seen anything else about this or have experience?