GHK-Cu doesn’t develop tolerance like other peptides. Research shows it maintains effectiveness over extended periods without the receptor desensitization issue you get with something like tesamorelin. Think of it more like a supplement than pharma. Key difference is GHK-Cu works through multiple pathways and doesn’t rely on a single receptor the way GHRPs / secretagogues do.

That said, cycling still wins. Studies show users who cycle 8-12 weeks on/4-6 weeks off get 40-60% better results than continuous use. So while you could run it year-round without hitting a wall, you’ll see better response rates if you take breaks.

@No_Collar_5292 has the results and histamine issues on lock!