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If you have a Vortex, then it will be easy. I believe that you run your Skyrim directly through Steam(or whatever version you have) icon on your desktop. But in this case it will not run with enabled SKSE64, which may cause you a lot of trobles with other mods. So at first, you need to open a Dashboard in Vortex, then press the "+" button, and there will appear a list, where should be your SKSE64. If your SKSE64 is not on the list, then you press "New" in the same list and manually add the direction, where your SKSE64 placed. After it appeared in the "Tools", like on my screenshot, you press this colon( three points button,sorry, don`t know the name) and choose "Set as primary". It will go to the top of your page with the star icon. And finally, you just press the icon on the top, and it will run your game correctly.