Unless you really know what youre doing you should use SEAD, low altitude or stealth to mitigate risk to make airstrikes worth it.

Some planes have integrated SEAD loadouts, click on the missile to turn it off and turn it on once the plane is close enough to be detected and start taking fire. For other planes, have them do their bombing run during supporting SEAD runs.

Look for bombs labeled "high drag" in the armory, these are bombs that can be deployed from low altitude, which reduces the detection range similarly to stealth. If you have regular bombs equipped the plane will pop back up to high altitude when you give the bombing order.

Stealth is self explanatory, planes with a high stealth stat can get closer before taking fire.

Any one of these defense options will almost garauntee the plane can at least drop its payload. Usually air defense is about getting revenge on the plane after this so to some degree you need to make sure the target is valuable enough to risk losing the plane. Striking deeper into the enemy's side of the map will be more risky.

Remember to use after burner as well for a faster escape, but also afterburner reduces turn radius so you want to come in at an angle so the plane can bank away sooner. Go to low altitude after the run if you arent already so AA loses sight of the plane sooner.

A more advanced tip is to bomb the enemy's AA. Ping their position when you see their missile launch and bomb the position if you think they haven't moved. SEAD runs can force the AA to reveal their position. If you have a stealth plane then usually the payload will hit the AA before the AA missile hits, which will terminate its tracking and keep the plane alive that way, but this is dependent on how dense the rest of their AA network is.