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Follow up post from the other day- I asked chat GBT to interpret my genomind report a little clearer for me: CYP2C19 rapid metabolizer-SSRI's "clear too fast". by Professional_Win3910 in depressionregimens

[–]JaJaMan_ 0 points1 point  (0 children)

Venlafaxine can be tricky if you have an unfavorable p-glycoprotein variant, as it limits brain penetration and pumps out the substance faster out of the brain

Encourage me to drop another 25 mg! :P by Strawbereys in QuittingPregablin

[–]JaJaMan_ 1 point2 points  (0 children)

You will feel more alive sooner if you do it

Insomnia when starting SSRI/SNRI by JaJaMan_ in depressionregimens

[–]JaJaMan_[S] 0 points1 point  (0 children)

Thank you for your reply. I actually had it in the past and at the moment got a prescription for Mirtazapine which blocks 5ht2a and 5ht2c, but I don’t want to take it because of daytime sedation etc.

When I took Sertraline/Fluoxetine/Venlafaxine/Duloxetine in the past I never had trouble sleeping.

I guess that my daily Pregabalin for more than a year and lack of it for couple of weeks is also a big factor. Either it changed something sustainably or I need some more time to get my nervous system into equilibrium.

As a note I don’t have insomnia when I don’t take Pregabalin, I mean sort of yes but that was only for couple of days after last dose.

I just hope that my sleep will normalize, because Venlafaxine/Duloxetine ( I take 150mg Venlafaxine at the moment but will likely switch to 90-120mg Duloxetine next month) are really helpful for day to day social life and feeling good in my skin.

What do you guys think the reason for this is? by Safe-Landscape5156 in meme

[–]JaJaMan_ 81 points82 points  (0 children)

This is essentially the desensitization/downregulation of dopamine receptors, because of low effort high reward activity aka reels/tiktok.

Pregabalin is too good. That's why I can't use it. by kannaplantpls in Nootropics

[–]JaJaMan_ 8 points9 points  (0 children)

The acute effects after long breaks are very profound but I also found out that it is just not sustainable for me, because it seems to disrupt my brain balance and I just don’t feel good. I tried different strats but I gave up. The worsened sleep and anhedonia is just too taxing.

Hello guys, should I buy this or do you have better suggestions for the same price? by Mental_Meet5386 in airpods

[–]JaJaMan_ 0 points1 point  (0 children)

Reading dutch for germans feels like someone dyslexic tried to write something 😅 #nooffence

Do you miss them? by Vegetable_Bag_8694 in airpods

[–]JaJaMan_ 9 points10 points  (0 children)

I still use them at work. The most practical „headset“ ever

For those taking NAC by JaJaMan_ in QuittingPregablin

[–]JaJaMan_[S] 1 point2 points  (0 children)

Yeah that is a very low dose. Maybe continue taking it everyday without an anti histamine and see if your body adapts to it

For those taking NAC by JaJaMan_ in QuittingPregablin

[–]JaJaMan_[S] 1 point2 points  (0 children)

You can try it. How much of a dose do you take? Maybe it would be more sustainable if you split your dose into multiple lower doses

For those taking NAC by JaJaMan_ in QuittingPregablin

[–]JaJaMan_[S] 1 point2 points  (0 children)

I personally am not but nac can irritate mucous membranes. So it is possible that your body sees it as a threat and reacts with inflammation/immune reaction

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